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Anti-inflammatory, analgesic, antitussive and antipyretic activities of polyphenol-enriched fraction from Nymphaea candida.
J Ethnopharmacol
April 2024
School of Toxicology, School of Public Health, Xinjiang Medical University, Urumqi, 830011, China. Electronic address:
Ethnopharmacological Relevance: "Snow-white waterlily" (Nymphaea candida) dried flower possesses various efficacy in Uighur medicine such as reducing fever and nourishing the liver, anti-inflammatory and cough relieving, moistening the throat and quenching thirst.
Aim Of The Study: Polyphenols are characteristic component of N. candida as well as its quality markers, and the purpose of this study was to conduct investigations into anti-inflammatory, antitussive, antipyretic, and analgesic activities of the polyphenol-enriched fraction from N.
Niosomes gel of apigenin to improve the topical delivery: development, optimization, permeation, antioxidant study, and evaluation.
Artif Cells Nanomed Biotechnol
December 2023
Department of Pharmacognosy, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Saudi Arabia.
Niosomes (NS) are the promising and novel carrier of the drug for effective transdermal delivery. Apigenin (AN) is a natural bioactive compound and has various pharmacological activities. AN is poorly water soluble which directly affects therapeutic efficacy.
View Article and Find Full Text PDFIsolation and characterization of ZK002, a novel dual function snake venom protein from with anti-angiogenic and anti-inflammatory properties.
Front Pharmacol
September 2023
Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Kowloon, Hong Kong SAR, China.
Pathological angiogenesis, the abnormal or excessive generation of blood vessels, plays an important role in many diseases including cancer, diabetic retinopathy, psoriasis, and arthritis. Additionally, increasing evidence supports the close linkage between angiogenesis and inflammation. Snake venoms are a rich natural source of biologically active molecules and carry rich potential for the discovery of anti-angiogenic and anti-inflammatory modulators.
View Article and Find Full Text PDFPyrazoles and Pyrazolines as Anti-Inflammatory Agents.
Molecules
June 2021
Department of Pharmaceutical Chemistry, School of Pharmacy, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.
The five-membered heterocyclic group of pyrazoles/pyrazolines plays important role in drug discovery. Pyrazoles and pyrazolines present a wide range of biological activities. The synthesis of the pyrazolines and pyrazole derivatives was accomplished the condensation of the appropriate substituted aldehydes and acetophenones, suitable chalcones and hydrazine hydrate in absolute ethanol in the presence of drops of glacial acetic acid.
View Article and Find Full Text PDF5-(4)-Oxazolones and Their Benzamides as Potential Bioactive Small Molecules.
Molecules
July 2020
Department of Pharmaceutical Chemistry, School of Pharmacy, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki 54124, Greece.
The five membered heterocyclic oxazole group plays an important role in drug discovery. Oxazolones present a wide range of biological activities. In this article the synthesis of 4-substituted-2-phenyloxazol-5(4)-ones from the appropriate substituted aldehydes via an Erlenmeyer-Plochl reaction is reported.
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