An increase in the power input for agitation from 0.4 to 2.7 kw/m3 in oxytetracycline biosynthesis stimulated the antibiotic production due to an accelerated use of carbohydrate and nitrogen and an earlier transition of the culture to the phase of the antibiotic biosynthesis. The procedure for determination of the aeration and agitation conditions by the maximum rate of the oxygen uptake is described. The procedure is recommended for the use in the studies on determination of such conditions for the biosynthesis of of oxytetracycline in large apparatus.
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