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Affinity descriptor of metal catalysts: concept, measurement and application of oxygen affinity in the catalytic transformation of oxygenates.
Chem Soc Rev
January 2025
National-local Joint Engineering Research Center of Biomass Refining and High-quality Utilization, Changzhou University, Changzhou 213164, China.
Multiple oxygenate groups in biomass-based feedstocks are open to multiple catalytic pathways and products, typically resulting in low selectivity for the desired products. In this context, strategies for rational catalyst design are critical to obtain high selectivity for the desired products in biomass upgrading. The Sabatier principle provides a conceptual framework for designing optimal catalysts by following the volcanic relationship between catalyst activity for a reaction and the binding strength of a substrate on a catalyst.
View Article and Find Full Text PDFβ-Glucuronidase-Responsive Albumin-Binding Prodrug of Colchicine-Site Binders for Selective cancer Therapy.
ChemMedChem
January 2025
UMR-CNRS 7285, Institut de Chimie des Milieux et des Matériaux de Poitiers, groupe « Systèmes Moléculaires Programmés », Faculté des Sciences Fondamentales et Appliquées, 4 rue Michel Brunet, TSA 51106, 86073, Poitiers, FRANCE.
The development of novel therapeutic strategies enabling the selective destruction of tumors while sparing healthy tissues is of great interest to improve the efficacy of cancer chemotherapy. In this context, we designed a β-glucuronidase-responsive albumin-binding prodrug programmed to release a potent Isocombretastatin A-4 analog within the tumor microenvironment. When injected at a non-toxic dose in mice bearing orthotopic triple-negative mammary tumors, this prodrug produced a significant anticancer activity, therefore offering a valuable alternative to the systemic administration of the parent drug.
View Article and Find Full Text PDFEngineering a Novel NIR RNA-Specific Probe for Tracking Stress Granule Dynamics in Living Cells.
Anal Chem
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Institute of Physical Science and Information Technology, Information Materials and Intelligent Sensing Laboratory of Anhui Province, Key Laboratory of Structure and Functional Regulation of Hybrid Materials of Ministry of Education, Anhui University, Hefei, Anhui 230601, China.
Real-time monitoring of the dynamics of cytosolic RNA-protein condensates, termed stress granules (SGs), is vital for understanding their biological roles in stress response and related disease treatment but is challenging due to the lack of simple and accurate methods. Compared with protein visualization that requires complex transfection procedures, direct RNA labeling offers an ideal alternative for tracking SG dynamics in living cells. Here, we propose a novel molecular design strategy to construct a near-infrared RNA-specific fluorescent probe () for tracking SGs in living cells.
View Article and Find Full Text PDFNanoparticle-aptamer based cytosensing for the detection of human non-small cell lung cancer cells.
Anal Methods
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Department of Oncology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, 646000, China.
This study reports a simple and rapid aptamer-based sensor platform designed for the sensitive and selective detection of human non-small cell lung cancer (NSCLC) cells. Under standard conditions, gold nanoparticles (AuNPs) remain dispersed and exhibit a characteristic peak at 520 nm. However, the addition of sodium chloride (NaCl) destabilizes the charge of the solution, leading to the aggregation of AuNPs.
View Article and Find Full Text PDFMolecular evidence for the role of the ovipositor of the fall armyworm: Where to lay or not to lay?
Insect Sci
January 2025
Institute of Plant Protection, Guangdong Academy of Agricultural Sciences, Key Laboratory of Green Prevention and Control on Fruits and Vegetables in South China Ministry of Agriculture and Rural Affairs, Guangdong Provincial Key Laboratory of High Technology for Plant Protection, Guangzhou, China.
Oviposition behavior in insects has received considerable attention, but studies have mainly focused on the antennae, neglecting the role of the ovipositor. In this study, we investigated the functional characteristics of the ovipositor in oviposition site selection by the fall armyworm (FAW) Spodoptera frugiperda, a destructive invasive pest of maize and other cereals. In oviposition choice assays females exhibited significant repellency to isothiocyanate (ITC), volatiles specific to non-preferred cruciferous plants.
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