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Symptoms Burden as a Clinical Outcomes Assessment in Heart Failure Patients With Atrial Fibrillation.
JACC Heart Fail
November 2024
Division of Cardiology, University of Colorado School Anschutz Medical Campus, Aurora, Colorado, USA; Cardiovascular Institute, University of Colorado School Anschutz Medical Campus, Aurora, Colorado, USA; ARCA Biopharma, Westminster, Colorado, USA. Electronic address:
Background: Safe and effective pharmacologic therapy for atrial fibrillation (AF) in heart failure (HF) is an unmet need. In AF clinical trials, the standard primary endpoint of time to first symptomatic AF event (TTFSE) has several disadvantages, which could theoretically be overcome by measurement of AF-specific symptoms burden during an entire follow-up period.
Objectives: The authors sought to develop and validate a method of measuring symptom burden of AF in a HF population.
Explainable machine learning model for predicting the risk of significant liver fibrosis in patients with diabetic retinopathy.
BMC Med Inform Decis Mak
November 2024
Artificial Intelligence Unit, Department of Medical Equipment Management, Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221004, Jiangsu Province, China.
Background: Diabetic retinopathy (DR), a prevalent complication in patients with type 2 diabetes, has attracted increasing attention. Recent studies have explored a plausible association between retinopathy and significant liver fibrosis. The aim of this investigation was to develop a sophisticated machine learning (ML) model, leveraging comprehensive clinical datasets, to forecast the likelihood of significant liver fibrosis in patients with retinopathy and to interpret the ML model by applying the SHapley Additive exPlanations (SHAP) method.
View Article and Find Full Text PDFA Comparison of GOLD and STAR Severity Stages in Individuals With COPD Undergoing Pulmonary Rehabilitation.
Chest
October 2024
Istituti Clinici Scientifici Maugeri IRCCS, Pulmonary Rehabilitation Unit of Telese Terme Institute, Italy; Department of Clinical Medicine and Surgery, Federico II University, Napoli, Italy. Electronic address:
Background: Alongside the recognized Global Initiative for Obstructive Lung Disease (GOLD) classification, the Staging of Airflow Obstruction by Ratio (STAR) severity scheme has been proposed for categorizing COPD.
Study Question: What are the agreement and utility of the GOLD and STAR classifications in patients with severe COPD entering the rehabilitation setting?
Study Design And Methods: Medical records were reviewed in this multicenter retrospective study, examining key functional variables and their changes in a large cohort of patients with COPD undergoing pulmonary rehabilitation.
Results: A total of 1,516 participants (33.
Refining Research Diagnostic Criteria for Catatonia Among Delirium, Medical, Affective, and Psychosis Patient Groups.
J Neuropsychiatry Clin Neurosci
January 2025
Department of Psychiatry, Indiana University School of Medicine, Indianapolis (Trzepacz); Grupo de Investigación en Psiquiatría de Enlace, Facultad de Medicina, Universidad Pontificia Bolivariana, Medellín, Colombia (Franco); Department of Psychiatry, Postgraduate Institute of Medical Education and Research, Chandigarh, India (Chakrabarti, Ghosh, Sahoo, Chakravarty, Grover).
Article Synopsis
- The authors proposed new diagnostic criteria for catatonia, called the Research Diagnostic Criteria for Catatonia (RDCC), which require three specific symptom clusters to improve diagnostic accuracy compared to existing methods.
- The RDCC categorizes symptoms into akinesia, unusual motor signs, and behavioral signs, and was tested on a diverse group of 341 patients across various conditions.
- Results indicated that using the RDCC resulted in significantly lower catatonia diagnoses among the patient groups when compared to DSM-5 and BFCRS criteria, suggesting a more restrictive approach may better identify true cases of catatonia.
Exploring risk factors and determinants: A scoping review of factors associated with nomophobia.
Indian J Psychiatry
July 2024
National Drug Dependence Treatment Centre, All India Institute of Medical Sciences, New Delhi, India.
Background: Nomophobia or no-mobile-phone phobia, defined as the fear of being unable to use or being unreachable via one's mobile phone. The pervasive concern has varied bio-psychosocial and clinical implications in an individual's life. Nomophobia is currently in an exploratory phase.
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