AI Article Synopsis
- The study analyzed bronchial concentrations of 11 different antibiotics in 280 patients, measuring how well these drugs penetrate bronchial secretions.
- The research found that penetration rates varied significantly between different antibiotics, even within the same class (like beta-lactams).
- Results indicated that levels of aminoglycosides, macrolides, and tetracyclines in bronchial secretions often exceeded the MIC necessary to combat infections, with penetration influenced by the inflammatory state of the bronchi.
Article Abstract
We report the results of the study of the bronchial concentrations of several antibiotics. The experiment included 280 patients and the concentrations achieved in bronchial secretions were measured for 11 antibiotics. The samples of bronchial secretions were taken in situ by fibroscopy or through the tracheostomy cannula. The results of the study show that the rate of penetration is variable according to the different drugs; even in the same antibiotic family such as beta-lactam antibiotics the rate of penetration is variable. The bronchial levels of aminoglycosides, macrolides and tetracyclines are worthwhile, and are often superior to the MIC of the infecting organisms; the penetration is also dependant of the inflammatory conditions of the bronchi. Otherwise the sampling conditions were the best possible since samples taken by fibroscopy or by tracheostomy are not contaminated by saliva which is a factor of dilutional error. The methodology used in this study is an approach of pharmacokinetics of antibiotics in respiratory tract.
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