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A Multi-Epitope Protein for High-Performance Serodiagnosis of Chronic Chagas Disease in ELISA and Lateral Flow Platforms.
Int J Mol Sci
September 2024
Center for Technological Development in Health, National Institute of Science and Technology for Innovation in Neglected Population Diseases, Oswald Cruz Foundation, Rio de Janeiro 21040-361, RJ, Brazil.
We developed a protein to rapidly and accurately diagnose Chagas disease, a life-threatening illness identified by the WHO as a critical worldwide public health risk. Limitations in present day serological tests are complicating the current health situation and contributing to most infected persons being unaware of their condition and therefore untreated. To improve diagnostic testing, we developed an immunological mimic of the etiological agent, , by combining ten pathogen-specific epitopes within the beta-barrel protein structure of Thermal Green Protein.
View Article and Find Full Text PDFImpact of Long-Term Pyriproxyfen Exposure on the Genetic Structure and Diversity of and in Manaus, Amazonas, Brazil.
Genes (Basel)
August 2024
Laboratório de Ecologia de Doenças Transmissíveis na Amazônia, Instituto Leônidas e Maria Deane-Fiocruz Amazônia, Manaus 69027-070, Brazil.
and are responsible for transmitting major human arboviruses such as Dengue, Zika, and Chikungunya, posing a global threat to public health. The lack of etiological treatments and efficient vaccines makes vector control strategies essential for reducing vector population density and interrupting the pathogen transmission cycle. This study evaluated the impact of long-term pyriproxyfen exposure on the genetic structure and diversity of and mosquito populations.
View Article and Find Full Text PDFFull genome sequence analysis of African swine fever virus isolates from Cameroon.
PLoS One
March 2024
The Pirbright Institute, Ash Road, Pirbright, Woking, Surrey, United Kingdom.
Article Synopsis
- African swine fever (ASF) is a serious virus affecting pigs, first identified in Georgia in 2007, and is caused by a large double-stranded DNA virus.
- The genetic diversity of ASFV comes from variations in certain multigene families, and changes in its genome happen slowly, making traditional sequencing methods less effective for tracking its evolution.
- Researchers report new full genome sequences from Cameroonian ASF isolates from 1982, 1994, and 2018, revealing novel genetic variations that could enhance studies on ASF epidemiology in Western Africa and elsewhere.
The aim of the article is to improve the differential diagnosis of specific and nonspecific inflammatory bowel diseases. In Russia, this scientific direction is associated with the name of G.F.
View Article and Find Full Text PDF[Epidemiological research and big data. The state of the art.].
Recenti Prog Med
June 2023
Dipartimento di Epidemiologia del Servizio sanitario regionale del Lazio, Asl Roma1.
Epidemiology, since its birth as a biomedical discipline to the present day, has progressively enriched and refined tools (and methodology) for research and generating evidence, adapting over time and in the context in which evidence is generated. In contemporary times, characterized by technological pervasiveness, increased computing power, and a global pandemic in an interconnected world, the paradigms of epidemiological research are opening up, at varying speeds depending on their real applicability, to a new, broader conception of "data" and more generally of its treatment. In this overview, we aim to take stock of what we know about this moment in epidemiology, where new research strands and "data-driven" analysis techniques are emerging alongside the traditional etiological vocation; a complex, ever-evolving scenario made up of lights, shadows, stimuli, and failures in which issues of method validity, professional training, and patients' right to privacy are increasingly central.
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