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What is the Best Approach to Removing the Social Stigma from the Diagnosis of Gender Dysphoria?
Health Care Anal
January 2025
Department of Endocrinology, Diabetes, and Metabolism, 'Elena Venizelou' General Hospital, Elena Venizelou Square 2, Athens, 11521, Greece.
Historically, the transgender population has faced prejudice and discrimination within society. The purpose of diagnostic terms is to direct clinical care and facilitate insurance coverage. However, the existence of a medical diagnosis for gender nonconformity can exacerbate the stigmatization of transgender people with adverse consequences on their emotional health and social life.
View Article and Find Full Text PDFCould Be a Promising Marker for Preoperative Diagnosis of High-Grade Papillary Thyroid Carcinoma?
Diagnostics (Basel)
November 2024
Department of the Structure and Function of Chromosomes, Institute of Molecular and Cellular Biology, Siberian Branch of the Russian Academy of Sciences, Novosibirsk 630090, Russia.
Background/objectives: A modern classification distinguishes between two nosological entities posing an intermediate risk between differentiated and anaplastic carcinoma: poorly differentiated thyroid carcinoma and differentiated high-grade thyroid carcinoma. There are currently few studies searching for the preoperative molecular genetic markers of high-grade papillary thyroid carcinoma (PTC HG), primarily because of a recent WHO reclassification and singling out of a separate entity: high-grade follicular cell-derived nonanaplastic thyroid carcinoma. Therefore, this work was aimed at identifying PTC HG-specific microRNAs and mRNAs that reliably distinguish them from differentiated papillary thyroid carcinoma in preoperative cytology specimens (fine-needle aspiration biopsies).
View Article and Find Full Text PDFTowards a consensus roadmap for a new diagnostic framework for mental disorders.
Eur Neuropsychopharmacol
January 2025
CNS Discovery Research, Boehringer Ingelheim Pharma GmbH, Biberach, Germany.
Article Synopsis
- Current mental disorder classifications are based on convention and symptom clusters rather than biological mechanisms, leading to significant overlap and variability in diagnoses.
- There is a need for a new diagnostic framework that incorporates neurobiology to enhance treatment options and help patients better understand their illnesses.
- The ECNP New Frontiers Meeting 2024 aims to establish a roadmap for improved precision diagnostics by focusing on innovative technologies, the biology of mental illness, and translating this knowledge into effective treatment strategies.*
Article Synopsis
- The 5th edition of the WHO classification of thyroid tumors reflects significant updates, particularly in molecular biology, influencing how traditional conditions are categorized and named.
- Terms have been modernized, such as referring to Hürthle cells as oncocytes, and new subtypes for follicular adenoma and non-invasive follicular thyroid neoplasm with papillary-like features (NIFTP) have emerged.
- A multidisciplinary treatment approach has led to the introduction of grading systems for various thyroid carcinomas, along with new classifications for rare tumors, including salivary gland-type carcinomas.
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