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Rare association between ankylosing spondylitis and paget's disease: A case of pagetic vertebral ankylosis.
Arch Osteoporos
December 2024
Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Erciyes University, 38030, Kayseri, Turkey.
Paget's disease is a condition marked by abnormal bone remodeling, involving both excessive bone formation and destruction, predominantly in the elderly. Pagetic vertebral ankylosis is a rare manifestation, often associated with Paget's disease, ankylosing spondylitis, or diffuse idiopathic skeletal hyperostosis. This form of acquired vertebral ankylosis is uncommon and occurs in cases with bone-bridging syndesmophytes or osteophytes.
View Article and Find Full Text PDFPrevalence of presumed endplate junction failure at the lumbosacral intervertebral junction in dogs on computed tomography.
Vet Radiol Ultrasound
September 2024
Division of Diagnostic Imaging, Department of Clinical Sciences, Faculty of Veterinary Medicine, Utrecht, The Netherlands.
Article Synopsis
- * A retrospective CT scan study on 324 dogs found that 21% had presumed EPJF and another 21% had annulus fibrosus rupture (AFF), which were often located at the last lumbar vertebra’s caudal endplate.
- * The study indicates that EPJF is linked to more severe IVDH grades and factors like age and certain spinal conditions, suggesting a need for further research to clarify its clinical significance and relationship to other spinal issues.
Causes of Musculoskeletal Pain in Paget's Disease of Bone.
Calcif Tissue Int
November 2024
Centre for Genomics and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, UK.
Article Synopsis
- Paget's disease of bone (PDB) makes bones grow and change shape in a messy way, which can lead to problems like pain, deafness, and broken bones.
- A study with 168 people found that about 73% of them had musculoskeletal pain, mainly because of osteoarthritis in joints away from the PDB affected areas.
- The research showed that pain was more common in older folks and women, and highlighted the need to check each person's pain to treat it correctly.
Acromegaly in humans and cats: Pathophysiological, clinical and management resemblances and differences.
Growth Horm IGF Res
June 2024
Pituitary Tumor Unit, Endocrinology Department, Hospital CUF Descobertas, Lisbon, Portugal; Faculdade de Medicina, Universidade Católica Portuguesa, Lisbon, Portugal. Electronic address:
Article Synopsis
- Acromegaly is a disorder caused by excess growth hormone (GH) and insulin-like growth factor-1 (IGF-1), leading to distinct physical changes and various health complications in both humans and cats.
- A literature review highlighted similarities and differences in how acromegaly manifests in these species, including craniofacial changes, joint issues, and cardiometabolic risks.
- Both species experience growth-related problems and associated diseases, but unique symptoms like human-specific skin conditions and different physical changes in cats distinguish their presentations.
Bone Remodeling in Osteoarthritis-Biological and Radiological Aspects.
Medicina (Kaunas)
September 2023
Department of Diagnostic and Interventional Radiology, University Hospital Dubrava, Avenija Gojka Suska 6, 10000 Zagreb, Croatia.
Among available papers published on the given subject over the last century, various terms have been used as synonyms for one, now generally accepted-osteoarthritis, in some countries called "wear and tear" or "overload arthritis". The opsolent terms-hypertrophic arthritis, degenerative arthritis, arthritis deformans and osteoarthrosis-sought to highlight the dominant clinical signs of this ubiquitous, polymorph disease of the whole osteochondral unit, which by incidence and prevalence represents one of the leading chronic conditions that cause long-term pain and incapacity for work. Numerous in vitro and in vivo research resulted in broadened acknowledgments about osteoarthritis pathophysiology and pathology on both histological and cellular levels.
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