Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/s0022-5347(17)53214-0 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Efficacy and Safety of Three Cycles of TIP and Sequential High Dose Chemotherapy in Patients with Testicular Non-Seminomatous Germ Cell Tumors.
J Clin Med
December 2024
Department of Medical Oncology, University of Health Sciences, Gulhane School of Medicine, Ankara 06018, Turkey.
: Salvage treatment options have not been validated in relapsed or refractory germ cell tumors. Moreover, the study populations including these patients have different heterogeneities. This study aimed to evaluate the efficacy and safety of three cycles of TIP sequential high-dose chemotherapy in patients with testicular non-seminomatous germ cell tumors who relapsed or had a refractory course after first-line platinum-based chemotherapy.
View Article and Find Full Text PDF[Clinicopathological significance of SOX2 and FOXG1 expression patterns in ovarian immature teratomas].
Zhonghua Bing Li Xue Za Zhi
December 2024
Department of Pathology, Third Hospital, School of Basic Medical Sciences, Peking University Health Science Center, Beijing100191, China.
To investigate the relationship between the expression patterns of SOX2 and FOXG1 and the differentiation/development level of neural components in immature teratoma and to determine the clinical significance and potential application of this correlation in a clinical setting. We conducted a comprehensive whole transcriptome sequencing analysis to identify differentially expressed genes (DEGs) across various subtypes of ovarian germ cell tumors. Additionally, immunohistochemical staining of paraffin-embedded tissue sections was employed to assess the nuclear staining pattern of SOX2 and FOXG1 proteins within the tumor tissues.
View Article and Find Full Text PDFMayfly developmental atlas: developmental temporal expression atlas of the mayfly, Ephemera vulgata, reveals short germ-specific hox gene activation.
BMC Genomics
December 2024
Biosystematics group, Wageningen University & Research, Droevendaalsesteeg 1, Wageningen, The Netherlands, 6708PB.
Article Synopsis
- The study focuses on the early developmental stages of the mayfly Ephemera vulgata, an ancient flying insect, to better understand ancestral modes of insect development which have been under-researched compared to more modern insects.
- Through DAPI staining and extensive RNA sequencing, researchers created a detailed expression atlas and identified over 6,000 differentially expressed genes across various developmental timepoints.
- The findings highlight a structured progression in embryonic development, revealing important correlations between genetic expression and the formation of major anatomical structures, as well as insights into the ancestral short germ segmentation process.
Maternal and zygotic contributions to H3K4me1 chromatin marking during germ layer formation.
Dev Biol
February 2025
Developmental and Cell Biology, University of California, Irvine, CA, USA; Center for Complex Biological Systems, University of California, Irvine, CA, USA. Electronic address:
An early step in triploblastic embryo differentiation is the formation of the three germ layers. Maternal pioneer transcription factors (TFs) bind to embryonic enhancers before zygotic genome activation, initiating germ layer specification. While maternal TFs' role in establishing epigenetic marks is known, how early pluripotent cells gain spatially restricted epigenetic identities remains unclear.
View Article and Find Full Text PDFAI-powered simulation-based inference of a genuinely spatial-stochastic gene regulation model of early mouse embryogenesis.
PLoS Comput Biol
November 2024
Frankfurt Institute for Advanced Studies (FIAS), Frankfurt am Main, Germany.
Understanding how multicellular organisms reliably orchestrate cell-fate decisions is a central challenge in developmental biology, particularly in early mammalian development, where tissue-level differentiation arises from seemingly cell-autonomous mechanisms. In this study, we present a multi-scale, spatial-stochastic simulation framework for mouse embryogenesis, focusing on inner cell mass (ICM) differentiation into epiblast (EPI) and primitive endoderm (PRE) at the blastocyst stage. Our framework models key regulatory and tissue-scale interactions in a biophysically realistic fashion, capturing the inherent stochasticity of intracellular gene expression and intercellular signaling, while efficiently simulating these processes by advancing event-driven simulation techniques.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!