The influence of 70-80% N2O on local local cerebral glucose utilization (CMRg1) in the rat brain was studied with the [14C]deoxyglucose method in minimally restrained, spontaneously breathing animals 75 min following discontinuation of halothane anaesthesia. Nitrous oxide was found to have only small effects on local CMRg1 in the majority of the 25 structures analyzed. When corrections were made for a small difference in body temperature between nitrous oxide--breathing animals and those breathing air nitrous oxide was found to significantly increase local CMRg1 in some subcortical structures by 15-25% (red nucleus, thalamus, geniculate bodies, and superior colliculus), and to decrease local CMRg1 in nucleus accumbens and sensorimotor cortex by comparable amounts. Thus, although nitrous oxide does not alter overall glucose utilization in the brain, it differentially affects CMRg1 in some brain structures.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1038/jcbfm.1982.55 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
A fatal case of accidental asphyxia following nitrous oxide inhalation and alcohol consumption.
Forensic Sci Med Pathol
January 2025
Department of Forensic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Nitrous oxide (NO) abuse is becoming increasingly popular worldwide. Moreover, the use of NO combined with other substances, such as alcohol, is also common. Accidental deaths associated with NO abuse are rare in forensic practice, with most fatal cases involving continuous inhalation equipment or exposure in a confined space.
View Article and Find Full Text PDFPhotochemistry of Microsolvated Nitrous Acid: Observation of the Water-Separated Complex of Nitric Oxide and Hydroxyl Radical.
J Phys Chem Lett
January 2025
Department of Chemistry, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Fudan University, Shanghai 200433, China.
The photochemistry of nitrous acid (HONO) plays a crucial role in atmospheric chemistry as it serves as a key source of hydroxyl radicals (OH) in the atmosphere; however, our comprehension of the underlying mechanism for the photochemistry of HONO especially in the presence of water is far from being complete as the transient intermediates in the photoreactions have not been observed. Herein, we report the photochemistry of microsolvated HONO by water in a cryogenic N matrix. Specifically, the 1:1 hydrogen-bonded water complex of HONO was facially prepared in the matrix through stepwise photolytic O oxidation of the water complex of imidogen (NH-HO) via the intermediacy of the elusive water complex of peroxyl isomer HNOO.
View Article and Find Full Text PDFEffects of Conservation Agriculture on Soil NO Emissions and Crop Yield in Global Cereal Cropping Systems.
Glob Chang Biol
January 2025
Key Laboratory of Mountain Surface Processes and Ecological Regulation, Institute of Mountain Hazards and Environment, Chinese Academy of Sciences, Chengdu, People's Republic of China.
Conservation agriculture, which involves minimal soil disturbance, permanent soil cover, and crop rotation, has been widely adopted as a sustainable agricultural practice globally. However, the effects of conservation agriculture practices on soil NO emissions and crop yield vary based on geography, management methods, and the duration of implementation, which has hindered its widespread scientific application. In this study, we assessed the impacts of no-tillage (NT), both individually and in combination with other conservation agriculture principles, on soil NO emissions and crop yields worldwide, based on 1270 observations from 86 peer-reviewed articles.
View Article and Find Full Text PDFSmaller sizes of polyethylene terephthalate microplastics mainly stimulate heterotrophic NO production in aerobic granular sludge systems.
Water Res X
May 2025
School of Environmental Science and Engineering, Tianjin University, Tianjin 300072, PR China.
Widespread polyethylene terephthalate microplastics (PET MPs) have played unintended role in nitrous oxide (NO) turnovers (i.e., production and consumption) at wastewater treatment plants (WWTPs).
View Article and Find Full Text PDFWhip-it Beyond Desserts: Causing Subacute Combined Degeneration - Case Report and Literature Review.
J Community Hosp Intern Med Perspect
January 2025
Internal Medicine Residency Program, Luminis Health Anne Arundel Medical Center, Annapolis, MD, USA.
Nitrous oxide (NO) has been increasingly used for recreational purposes due to its dissociative and euphoric properties. Exposure to NO results in the deactivation of in vivo vitamin B, leading to subsequent neurological sequelae due to vitamin B deficiency.7 Current management focuses on cessation of exposure and replacement therapy, yet patients may continue to suffer from permanent neurological damage.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!