When mice were given water diet with 57Fe a practically complete exchange in the blood 56Fe and 57Fe was observed during 2 months. 57Fe isotope was accumulated in iron storage of the liver, kidney and spleen. Partial isotope exchange for free iron occurred in these tissues too. The free iron content was not changed. This isotope exchange for free iron did not occur in tissues which were unable to accumulate 57Fe in iron storage.
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