AI Article Synopsis
- A multicentre, double-blind study tested the pain relief of pirprofen (200 and 400 mg) and pentazocin (100 mg) against a placebo in 210 post-oral surgery patients.
- Both pirprofen and pentazocin were more effective than placebo, with pirprofen showing greater pain relief than pentazocin at both doses.
- The 400 mg dose of pirprofen was significantly more effective than the 200 mg dose, providing noticeable analgesia within 15 minutes, with only one patient experiencing diarrhoea as a side effect.
Article Abstract
In this multicentre, double-blind clinical study, the pain-relieving effects of single doses of pirprofen (200 and 400 mg) and pentazocin (100 mg) were compared with those of a placebo in 210 patients after oral surgery. Pirprofen and pentazocin were significantly more effective than the placebo. At either of the two dosage levels, pirprofen proved more active than pentazocin. A dose-activity ratio could be established with pirprofen and showed that the 400 mg dose was distinctly more effective than the 200 mg dose (p less than 0.05). The analgesia procured by the drug was perceptible after about 15 minutes. One of the 51 patients who received the 400 mg dose developed diarrhoea, this being the only side effect observed.
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