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Microfluidic-Chip-Based Formulation and In Vivo Evaluations of Squalene Oil Emulsion Adjuvants for Subunit Vaccines.
Vaccines (Basel)
November 2024
GSK, Rockville Centre for Vaccines Research, Rockville, MD 20850, USA.
Background: Adjuvants play a crucial role in improving the immunogenicity of various antigens in vaccines. Squalene-in-water emulsions are clinically established vaccine adjuvants that improve immune responses, particularly during a pandemic. Current manufacturing processes for these emulsion adjuvants include microfluidizers and homogenizers and these processes have been used to produce emulsion adjuvants to meet global demands during a pandemic.
View Article and Find Full Text PDFNon-Invasive Malaria Detection in Sub-Saharan Africa Using a DNA-Based Sensor System.
Sensors (Basel)
December 2024
Department of Molecular Biology and Genetics, Universitetsbyen 81, Aarhus University, 8000 Aarhus, Denmark.
Malaria poses a serious global health problem, with half the world population being at risk. Regular screening is crucial for breaking the transmission cycle and combatting the disease spreading. However, current diagnostic tools relying on blood samples face challenges in many malaria-epidemic areas.
View Article and Find Full Text PDFOpportunistic Weather Sensing by Smart City Wireless Communication Networks.
Sensors (Basel)
December 2024
School of Electrical Engineering, Tel Aviv University, P.O. Box 39040, Tel Aviv 6997801, Israel.
This paper presents how the concept of opportunistic integrated sensing and communication (ISAC), focusing on weather sensing, is incorporated into wireless smart cities' networks. The concept, first introduced in 2006, utilized standard signal level measurements from wireless backhaul cellular networks for rain monitoring. Since then, it has expanded to include technologies like satellite communication and smart cities' networks.
View Article and Find Full Text PDFImproving Phosphate Acquisition from Soil via Higher Plants While Approaching Peak Phosphorus Worldwide: A Critical Review of Current Concepts and Misconceptions.
Plants (Basel)
December 2024
Institut für Angewandte Wissenschaft, Ausbau 5, 18258 Rukieten, Germany.
Phosphate (P) is the plant macronutrient with, by far, the lowest solubility in soil. In soils with low P availability, the soil solution concentrations are low, often below 2 [µmol P/L]. Under these conditions, the diffusive P flux, the dominant P transport mechanism to plant roots, is severely restricted.
View Article and Find Full Text PDFThe Role of Antioxidant Plant Extracts' Composition and Encapsulation in Dietary Supplements and Gemmo-Derivatives, as Safe Adjuvants in Metabolic and Age-Related Conditions: A Review.
Pharmaceuticals (Basel)
December 2024
Faculty of Pharmacy, Ovidius University of Constanta, 6, Capitan Aviator Al. Serbanescu Str., 900470 Constanta, Romania.
Given the current global circumstances, marked by severe environmental pollution-including the contamination of food-along with daily stress and a sedentary lifestyle, many consumers choose to improve their quality of life by using, among others, minimally processed food, food supplements, and gemmo-derivatives. Recent lab and clinical studies have shown the positive impact of specific nutrients with antioxidant capacities in the treatment of several conditions generated by oxidative stress. This paper reviews antioxidant plant extracts utilized as components in various dietary supplements and gemmoderivatives, highlighting their chemical composition and biological properties in preventing diseases caused by oxidative stress.
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