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Myocardial mechanics and energetics during continuous positive airway pressure in sedated pigs.
Crit Care Med
December 1996
Division of Pulmonary and Critical Care Medicine, Long Island Jewish Medical Center, Albert Einstein College of Medicine, New Hyde Park, NY, USA.
Objective: To test the hypothesis that increased cardiac output with continuous positive airway pressure (CPAP) leads to increased myocardial metabolic cost.
Design: Prospective, repeated-measures, laboratory studies.
Setting: University-affiliated hospital animal research laboratory.
The auditory evoked response (AER) has been studied in six patients before the induction of general anaesthesia, during anaesthesia with nitrous oxide in oxygen and mechanical ventilation, then with a stepwise increasing rate of infusion of Althesin ranging from 18 micrograms kg-1 min 1 to 90 micrograms kg-1 min-1. The sections of the AER examined in this study were the brainstem waves I, III and V and the early cortical waves Pa and Nb. There were dose-related changes in latency and amplitude of waves Pa and Nb, latency increasing and amplitude diminishing with increasing concentrations of alphaxalone as measured in venous blood.
View Article and Find Full Text PDFThe human basophil degranulation test (HBDT) studies the allergic response of effector cells. In this work, it was used in the diagnosis of anaphylactoid reactions during anaesthesia. Thirteen patients having had an anaphylactoid shock during general anaesthesia were investigated.
View Article and Find Full Text PDFChronopharmacology involves the investigation of drug effects as a function of biological time and the investigation of drug effects on rhythm characteristics. Three new concepts must be considered: (a) the chronokinetics of a drug, embracing rhythmic (circadian) changes in drug bioavailability (or pharmacokinetics) and its excretion (urinary among others); (b) the chronaesthesia of a biosystem to a drug, i.e.
View Article and Find Full Text PDFSpecific effects of drugs at pressure: animal investigations.
Philos Trans R Soc Lond B Biol Sci
January 1984
The interactions of anaesthetics and other drugs with high pressure suggest that protection against the high pressure neurological syndrome (h.p.n.
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