Records of heights and weights kept for more than 25 years for two neighbouring Gambian villages have been used to describe the pattern of growth. There was no secular trend in height. Children who died during the investigation were smaller and lighter than the survivors, but the interval between the last available dry-season measurement and death was not associated with the degree of deficit in height and weight. The presence of seasonal variation in the rates of growth in height and weight was shown, the lowest rates occurring during late rains (August to November). Height growth curves from the age of 5 to 23-25 years were fitted for 55 boys and 62 girls. The curves indicate that puberty is much delayed in Gambian adolescents in comparison to British and West Bengal data. The mean age at peak height velocity (PHV) was 16.3 and 13.8 years for boys and girls respectively. The corresponding velocities were 6.9 and 6.0 cm/yr. In girls but not in boys there was a significant negative correlation (-0.46) between the age at PHV and PHV itself. There was no significant correlation between the age at PHV and adult height. Comparison with British data suggests that growth patterns in the Gambian villages are characterized by the substantial deficits in both height and weight that develop in early life and which appear to persist without rectification into adulthood.
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http://dx.doi.org/10.1080/03014468200005811 | DOI Listing |
Microb Genom
March 2024
Department of Clinical Research, London School of Hygiene & Tropical Medicine, London, UK.
Trachoma, a neglected tropical disease caused by (Ct) serovars A-C, is the leading infectious cause of blindness worldwide. Africa bears the highest burden, accounting for over 86 % of global trachoma cases. We investigated Ct serovar A (SvA) and B (SvB) whole genome sequences prior to the induction of mass antibiotic drug administration in The Gambia.
View Article and Find Full Text PDFInfant Behav Dev
March 2024
The BRIGHT Project team, UK.
Trials
April 2023
Medical Research Council Unit The Gambia at London School of Hygiene & Tropical Medicine, PO Box 273, Fajara, Banjul, The Gambia.
The COVID-19 pandemic represents an unprecedented challenge for clinical research. The Pneumococcal Vaccine Schedules (PVS) study is a non-inferiority, interventional trial in which infants resident in 68 geographic clusters are randomised to two different schedules for pneumococcal vaccination. From September 2019 onwards, all infants resident in the study area became eligible for trial enrolment at all Expanded Programme on Immunisation (EPI) clinics in the study area.
View Article and Find Full Text PDFMalar J
June 2022
Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Ashworth Laboratories, Kings Buildings, Charlotte Auerbach Rd, Edinburgh, EH9 3FL, UK.
Malar J
February 2022
Department of Biosciences, Durham University, Durham, UK.
Background: The World Health Organization recommends house screening as a tool for malaria control, yet evidence of the long-term durability, functionality and acceptability of this intervention is lacking. In this study, the sustainability and use of novel types of screened doors and windows was examined 4 years after installation in a Gambian village.
Methods: A survey of 31 houses, each with two screened doors and two screened windows, was conducted in the rainy season.
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