457 Klebsiella strains isolated from newborns and young children with different clinical manifestations of infections, as well as from adults having contacts with them and from various objects of the environment in the foci of these infections, have been studied. All the isolated cultures, with the exception of one strain isolated from the pus of a gluteal abscess and identified as K. ozaenae K4, have been identified as K. pneumoniae. The use of experimental Klebsiella K-sera has allowed one to establish the presence of 27 K-antigen varieties in K. pneumoniae; among them K2, K9, K10, K13, K18, K20, K24, K33, K46, K47 have been found to occur most frequently . In group diseases of infants serovars K2, K9, K10, K18, K20, K24, K33 have been identified, serovars K9, K10 and K20 being detected for the first time in such cases. The data confirming the etiological role of the isolated Klebsiella organisms point out to the necessity of maintaining the constant microbiological control of Klebsiella infection in maternity homes and children's somatic hospitals.
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Cell Mol Life Sci
December 2021
Cell Biology, Biosciences, Faculty of Science and Engineering, Åbo Akademi University, BioCity, Tykistökatu 6A, N20520, Turku, Finland.
Keratin 8 (K8) is the main intestinal epithelial intermediate filament protein with proposed roles for colonic epithelial cell integrity. Here, we used mice lacking K8 in intestinal epithelial cells (floxed K8 and Villin-Cre1000 and Villin-CreER) to investigate the cell-specific roles of intestinal epithelial K8 for colonocyte function and pathologies. Intestinal epithelial K8 deletion decreased K8 partner proteins, K18-K20, 75-95%, and the remaining keratin filaments were located at the colonocyte apical regions with type II K7, which decreased 30%.
View Article and Find Full Text PDFJ Mol Graph Model
May 2020
Computational Biology and Molecular Simulations Laboratory, Department of Biophysics, School of Medicine, Bahcesehir University, Istanbul, 34353, Turkey. Electronic address:
The human ether-a-go-go related gene 1 (hERG1) K channels play crucial role in the heart, different regions of brain, endocrine cells, smooth muscle cells, and numerous tumor cells. It is known that the inherited mutations of hERG1 gene may lead to the disorder of cardiac repolarization (i.e.
View Article and Find Full Text PDFOncol Lett
December 2016
Department of Pathology, Kansai Medical University, Moriguchi, Osaka 570-8506, Japan.
It has been hypothesized that milia originate from the hair bulge of the outer root sheath. To elucidate the histogenesis of milia, an immunohistochemical study was performed using anti-keratin and anti-filaggrin antibodies to determine the levels of keratin and filaggrin expression. Keratin expression was evaluated using anti-keratin antibodies against K1, K7, K8, K10, K14, K15, K16, K17, K18, K19 and K20.
View Article and Find Full Text PDFCells
September 2016
Faculty of Science and Engineering, Cell Biology/Biosciences, Åbo Akademi University, Tykistökatu 6A, 20520 Turku, Finland.
Keratin (K) intermediate filaments can be divided into type I/type II proteins, which form obligate heteropolymers. Epithelial cells express type I-type II keratin pairs, and K7, K8 (type II) and K18, K19 and K20 (type I) are the primary keratins found in the single-layered intestinal epithelium. Keratins are upregulated during stress in liver, pancreas, lung, kidney and skin, however, little is known about their dynamics in the intestinal stress response.
View Article and Find Full Text PDFJ Transl Med
July 2016
McGill University, MUHC Royal Victoria Hospital, Montreal, QC Canada
MELANOMA BRIDGE 2015 KEYNOTE SPEAKER PRESENTATIONS Molecular and immuno-advances K1 Immunologic and metabolic consequences of PI3K/AKT/mTOR activation in melanoma Vashisht G. Y. Nanda, Weiyi Peng, Patrick Hwu, Michael A.
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