Two cases of severe intrahepatic cholestasis due to amyloidosis of the liver seen within 9 months are described and compared with the pertinent literature. In both, the diagnosis was established by needle biopsy of the liver, and the amyloidosis associated with a myeloma. The methods available for reaching a definite diagnosis are discussed, and the possible diagnostic importance of percutaneous transhepatic cholangiography, as performed in one of the two patients, is stressed. Amyloidosis of the liver complicated by jaundice is possibly not such a rare disease; it has a very poor prognosis, and the patients do not survive more than a few months.
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