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Severe local and systemic haematotoxic envenoming caused by a Malayan pit viper (Calloselasma rhodostoma) in a pregnant woman in Lao People's Democratic Republic.
Toxicon
January 2025
Emergency Department, Setthatirath Hospital, Vientiane, Laos.
Snakebite envenoming in pregnant women is rare, accounting for approximately 0.5-1.8% of all snakebite cases.
View Article and Find Full Text PDFVenom composition, toxicity and cross-neutralization by PoliVal-ICP antivenom, of Mesoamerican jumping pitvipers genus Metlapilcoatlus (Viperidae: Crotalinae).
Trans R Soc Trop Med Hyg
January 2025
Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José 11501, Costa Rica.
Background: The genus Metlapilcoatlus was recently erected to include six species of stout venomous snakes, known as the jumping pitvipers, which inhabit mountainous areas of Mesoamerica. This group maintains affinity with Atropoides picadoi, another jumping pitviper with restricted distribution in Costa Rica and Panama. Although the venom of A.
View Article and Find Full Text PDFCorticosterone, lactate, and circulating leukocyte responses of free-ranging cottonmouth snakes (Agkistrodon piscivorus) vary with the duration and nature of the acute stressor.
Gen Comp Endocrinol
January 2025
Biological Sciences, Southeastern Oklahoma State University, Durant, OK 74701, USA.
Exposure to acute stressors can induce multiple physiological changes in vertebrates such as altering circulating hormone and enzyme levels as well as leukocyte counts, and interactions between endocrine and immune function may produce suites of physiological changes following acute stress. Previously, we showed that presence of human observers elicited only a weak elevation of plasma corticosterone levels in cottonmouths. Additional variables, however, must be considered to understand if changes in physiological parameters are highly generalized or vary among sexes or with context.
View Article and Find Full Text PDFJararaca GPIb-binding protein causes thrombocytopenia during Bothrops jararaca envenomation.
Sci Rep
December 2024
Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina.
Inoculation of Bothrops jararaca snake venom (BjV) induces thrombocytopenia in humans and various animal species. Although several BjV toxins acting on hemostasis have been well characterized in vitro, it is not known which one is responsible for inducing thrombocytopenia in vivo. In previous studies, we showed that BjV incubated with metalloproteinase or serine proteinase inhibitors and/or anti-botrocetin antibodies still induced thrombocytopenia in rats and mice.
View Article and Find Full Text PDFBicistronic Vector Expression of Recombinant Jararhagin-C and Its Effects on Endothelial Cells.
Toxins (Basel)
December 2024
Immunopathology Laboratory, Butantan Institute, São Paulo 05585-090, Brazil.
Jararhagin-C (JarC) is a protein from the venom of consisting of disintegrin-like and cysteine-rich domains. JarC shows a modulating effect on angiogenesis and remodeling of extracellular matrix constituents, improving wound healing in a mouse experimental model. JarC is purified from crude venom, and the yield is less than 1%.
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