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Duodenogastric Reflux in Health and Disease: Insights from a Computational Fluid Dynamics Model of the Stomach.
Am J Physiol Gastrointest Liver Physiol
January 2025
Department of Mechanical Engineering, Johns Hopkins University, Baltimore, Maryland 21218, USA.
The stomach is responsible for physically and chemically processing the ingested meal before controlled emptying into the duodenum through the pyloric sphincter. An incompetent pylorus allows reflux from the duodenum back into the stomach, and if the amount of reflux is large enough, it could alter the low pH environment of the stomach and erode the mucosal lining of the lumen. In some cases, the regurgitated contents can also reach the esophagus leading to additional complications.
View Article and Find Full Text PDFComparisons in Postoperative Endoscopic Findings and Postoperative Weight Change Between Delta-Shaped Anastomosis and Circular-Stapled Anastomosis in Laparoscopy-Assisted Distal Gastrectomy With B-I Reconstruction.
Asian J Endosc Surg
January 2025
Division of Advanced Surgical Oncology, Research and Development Center for New Medical Frontiers, Kitasato University School of Medicine, Sagamihara, Japan.
Background: Laparoscopy-assisted distal gastrectomy (LADG) with Billroth I (B-I) reconstruction is frequently performed for gastric cancer. However, the difference between the circular stapler technique (CS) and delta-shaped anastomosis (DA) remains unclear, especially regarding the postoperative endoscopic physiological findings.
Methods: Three hundred and one patients including 150 CS patients and 151 DA patients during LADG with B-I reconstruction between 2013 and 2019 at Saitama Medical University International Medical Center were chosen as study subjects.
Current status of evaluation and treatment of early-stage remnant gastric cancer.
Front Oncol
November 2024
Department of Gastroenterology, The Affiliated Hospital of Qingdao University, Qingdao, China.
Article Synopsis
- Early detection and better treatment options are helping gastric cancer patients live longer, leading to a rise in cases of remnant gastric cancer after surgery.
- Traditionally linked to poor survival rates, recent advancements in diagnosis and endoscopic therapy are enhancing treatment outcomes for this condition.
- The review highlights the importance of understanding remnant gastric cancer's development and advocates for regular endoscopic surveillance to catch any early signs of cancer in post-gastrectomy patients.
The Impact of Cholecystectomy on Bile Reflux After One Anastomosis Gastric Bypass.
Obes Surg
January 2025
Center of Excellence of European Branch of International Federation for Surgery of Obesity, Hazrat-e Rasool Hospital, Tehran, Iran.
Background: Bile reflux (BR) is an issue after one anastomosis gastric bypass (OAGB). Cholecystectomy can increase BR in patients without a history of metabolic and bariatric surgery. We aimed to evaluate the effect of cholecystectomy on BR after OAGB.
View Article and Find Full Text PDFSesquiterpene-enriched extract of Chinese agarwood (Aquilaria sinensis) alleviates bile reflux gastritis through suppression of gastric mucosal cell apoptosis via the Wnt/β-catenin signaling pathway.
J Ethnopharmacol
February 2025
Beijing Research Institute of Chinese Medicine, Beijing University of Chinese Medicine, Beijing, 100029, China. Electronic address:
Ethnopharmacological Relevance: Chinese agarwood (Aquilaria sinensis) has been a traditional treatment for digestive disorders in South and East Asia. While sesquiterpenes are recognized as the key active constituents of Chinese agarwood, the efficacy and mechanism of the sesquiterpene-enriched extract of Chinese agarwood (PEE) on bile reflux gastritis (BRG) remain unclear.
Aim Of The Study: To explore the protective impact of PEE against BRG and unveil its underlying mechanism in suppressing apoptosis of gastric mucosal cells.
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