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Graves' Disease-Induced Psychosis Refractory to Intensive Medical Management Requiring Non-voluntary Thyroidectomy for Psychosis Resolution: A Case Report.
Cureus
January 2024
Endocrinology and Diabetes, Hennepin County Medical Center, Minneapolis, USA.
Graves' disease is an autoimmune disorder characterized by hyperthyroidism, ophthalmopathy, and dermatopathy. The chief thyroid hormone abnormality is the elevation of thyroid hormone, resulting in an overexcitation of the sympathetic and central nervous systems. Psychosis due to Graves' disease is rarely the first presenting symptom, but it is an essential complication of those with severe or untreated disease.
View Article and Find Full Text PDFThe Intertwined Relationship Between an Overactive Thyroid and an Overactive Mind: A Case Report and Review of Literature.
Cureus
December 2023
Psychiatry, The Wright Center for Graduate Medical Education, Scranton, USA.
This case report presents the clinical scenario of a 45-year-old male patient who exhibited acute psychiatric symptoms as the initial manifestation of Graves' disease, a common etiology of hyperthyroidism. The patient presented with severe agitation, persecutory delusions, and auditory hallucinations, raising concerns about his mental health. Detailed diagnostic evaluations revealed thyroid dysfunction characterized by markedly low thyroid-stimulating hormone (TSH) levels, elevated free T4 levels, and increased total T3 levels, indicative of thyrotoxicosis.
View Article and Find Full Text PDFCatatonia and Psychosis Associated With Hyperthyroidism.
Prim Care Companion CNS Disord
November 2023
Department of Psychiatry, Wake Forest School of Medicine, Winston-Salem, North Carolina.
Psychosis secondary to thyrotoxicosis that persisted post-thyroidectomy: a case report.
BMC Psychiatry
October 2023
University of Mississippi Medical Center Jackson, MS 39216, Jackson, USA.
Background: This case report is of a patient with psychosis secondary to thyrotoxicosis that persisted and reemerged after definitive treatment of thyroidectomy, which is a unique occurrence in the literature.
Case Presentation: This patient is a male between 30 and 35 years of age with a history of Graves Disease and no past psychiatric history who was admitted to the hospital due to psychosis secondary to thyrotoxicosis. The thyrotoxicosis was treated with surgical removal, but the psychotic symptoms persisted after surgery and normalization of standard thyroid functional measures.
Acute Psychosis Related to Primary Hyperparathyroidism in a Patient With Bipolar Disorder.
Cureus
July 2023
Geriatrics, Barking, Havering and Redbridge University Hospitals NHS Trust, London, GBR.
Primary hyperparathyroidism (PHPT) can cause hypercalcemia secondary to high parathyroid hormone secretion. Hyperparathyroidism- and hypercalcemia-related acute psychotic symptoms can be challenging to diagnose in patients with mental health-related disorders, and it should be considered a possible differential in these patients besides medications. It can sometimes be the first manifestation of the disease, and diagnosis can be challenging, especially in patients with a previous psychiatric history without checking their biochemistry profile.
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