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Zingerone effect against Candida albicans growth and biofilm production.
J Mycol Med
December 2024
Department of Stem Cell and Regenerative Medicine and Medical Biotechnology, Centre for Interdisciplinary Research, DY Patil Education Society (Deemed to be University), Kolhapur, Maharashtra, 416003, India. Electronic address:
Background: The increasing resistance of Candida albicans biofilms underscores the urgent need for effective antifungals. This study evaluated the efficacy of zingerone and elucidated its mode of action against C. albicans ATCC 90028 and clinical isolate C1.
View Article and Find Full Text PDFExploring the anti-biofilm and gene regulatory effects of anti-inflammatory drugs on Candida albicans.
Naunyn Schmiedebergs Arch Pharmacol
December 2024
Department of Medical Parasitology and Mycology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Researchers have repurposed several existing anti-inflammatory drugs as potential antifungal agents in recent years. So, this study aimed to investigate the effects of anti-inflammatory drugs on the growth, biofilm formation, and expression of genes related to morphogenesis and pathogenesis in Candida albicans. The minimum inhibitory concentration (MIC) of anti-inflammatory drugs was assessed using the broth microdilution method.
View Article and Find Full Text PDFThe 24-kDa subunit of mitochondrial complex I regulates growth, microsclerotia development, stress tolerance, and virulence in Verticillium dahliae.
BMC Biol
December 2024
State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing, 100193, China.
Background: The complete mitochondrial respiratory chain is a precondition for maintaining cellular energy supply, development, and metabolic balance. Due to the evolutionary differentiation of complexes and the semi-autonomy of mitochondria, respiratory chain subunits have become critical targets for crop improvement and fungal control. In fungi, mitochondrial complex I mediates growth and metabolism.
View Article and Find Full Text PDFMitogen-activated protein (MAP) kinase signalling pathway VmMkh1-VmMkk1-VmSpm1 regulates cell wall integrity in Valsamali.
Microb Pathog
January 2025
Shandong Research Center for Forestry Harmful Biological Control Engineering and Technology, College of Plant Protection, Shandong Agricultural University, Tai'an, 271018, Shandong, China. Electronic address:
Article Synopsis
- Apple Valsa canker disease, caused by Valsa mali, threatens apple tree growth, and this study explores the role of specific MAPK signaling pathway components (VmMkh1, VmMkk1, and VmSpm1) in this process.
- Deletion of these components slows growth, reduces the production and germination of conidia, and hampers survival under stress conditions (like high salinity and cell wall disruptors).
- The research indicates that these components are crucial in regulating various aspects like growth, stress response, and pathogenicity associated with Valsa mali.
The Cwr1 protein kinase localizes to the plasma membrane and mediates resistance to cell wall stress in .
mSphere
December 2024
Department of Microbiology and Immunology, Stony Brook University, Stony Brook, New York, USA.
Unlabelled: The plasma membrane is critical for the virulence of the human fungal pathogen . In addition to functioning as a protective barrier, the plasma membrane plays dynamic roles in a wide range of functions needed for virulence including nutrient uptake, cell wall synthesis, morphogenesis, resistance to stress, and invasive hyphal growth. Screening a collection of mutants identified an understudied gene that is important for invasive hyphal growth, which we have termed (Cell Wall Regulatory kinase).
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