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Hydrogen sulfide attenuates disturbed flow-induced vascular remodeling by inhibiting LDHB-mediated autophagic flux.
Redox Biol
February 2025
Department of Cardiology, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, China. Electronic address:
Disturbed flow (DF) plays a critical role in the development and progression of cardiovascular disease (CVD). Hydrogen sulfide (HS) is involved in physiological processes within the cardiovascular system. However, its specific contribution to DF-induced vascular remodeling remains unclear.
View Article and Find Full Text PDFLactate dehydrogenase-1 may play a key role in the brain energy disturbance caused by cryptococcal meningitis.
J Microbiol Immunol Infect
December 2024
Infectious Disease Laboratory, Guangxi AlDs Clinical Treatment Center (Nanning)/The Fourth People's Hospital of Nanning, Nanning, Guangxi, China; Department of Internal Medicine, Guangxi AlDs Clinical Treatment Center (Nanning)/The Fourth People's Hospital of Nanning, Nanning, Guangxi, China. Electronic address:
Article Synopsis
- Cryptococcal meningitis (CM) disrupts the conversion of lactate to pyruvate in the brain, leading to abnormal adenosine triphosphate (ATP) levels, primarily due to the role of lactate dehydrogenase 1 (LDH1).
- A study collected cerebrospinal fluid (CSF) from 17 patients, examining various biochemical markers, and found that patients with CM had increased intracranial pressure and white cell counts, along with altered levels of LDH1, pyruvate, and ATP compared to non-infectious disease patients.
- The findings indicate that reduced LDH1 levels contribute to increased lactate and decreased pyruvate and ATP, adversely impacting
Development of a one-plasmid system to replace the endogenous protein with point mutation for post-translational modification studies.
Mol Biol Rep
January 2022
Department of Digestive Disease, The First Affiliated Hospital of USTC, Anhui Provincial Hospital, University of Science and Technology of China, Hefei, China.
Background: Post-translational modification (PTM) is one of the major regulatory mechanism for protein activities. To understand the function of PTMs, mutants that prevent or mimic the modification are frequently utilized. The endogenous proteins are usually depleted while the point mutations are expressed.
View Article and Find Full Text PDFEffect of intestinal lymphatic circulation blockage in two-hit rats.
World J Gastroenterol
September 2006
Institute of Cell Biology, Zhejiang University, Hangzhou 310003, Zhejiang Province, China.
Aim: To study the effect of blocking intestinal lymphatic circulation in two-hit rats and explore the significance of intestinal lymphatic circulation in two-hit.
Methods: Wistar rats were divided equally into three groups: mesenteric lymph duct ligation group, non-ligation group and sham group. Mesenteric lymph was diverted by ligation of mesenteric lymph duct, and the two-hit model was established by hemorrhage and lipopolysaccharide (LPS) methods.
Unlabelled: During 1992 1996 we observed 122 children with diphtheria, 49 with the toxic form, in the region of Nizhny Novgorod in Russia. Sixty-four patients suffered from diphtheric carditis, 9 died. The clinical picture was characterized by a rapid development of heart and circulatory failure.
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