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Are We (and Can We Be) Genuinely Inclusive? Hos[ti]pitality in Occupational Therapy Education, Practice, and Research.
Am J Occup Ther
March 2025
Razan Hamed, PhD, OTR/L, FAOTA, is Associate Professor, Occupational Therapy, Rehabilitation and Regenerative Medicine, Columbia University, New York, NY.
Inclusion and belonging are fundamental human needs and key to the engagement and well-being of occupational therapy practitioners, scientists, educators, and learners. Despite this, the profession has struggled throughout its history to act on its values as focused on wide-ranging perspectives of occupational engagement in diverse cultural contexts. Issues of diversity, equity, inclusion, justice, and accessibility (DEIJA) innervate contemporary discourse, but there is a real danger that these conversations remain at a superficial level and stop short of attempts at genuine disruption of the deeply rooted colonial systems that exist in the profession.
View Article and Find Full Text PDFUpdate on the connectivity of the paraventricular nucleus of the thalamus and its position within limbic corticostriatal circuits.
Neurosci Biobehav Rev
February 2025
Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba R3E 0W2, Canada. Electronic address:
The paraventricular nucleus of the thalamus (PVT) is generating interest because evidence establishes a role for this midline thalamic nucleus in behavior. Early tracing studies demonstrated that afferent fibers from the PVT and limbic cortex converge with dopamine fibers within subcompartments of the ventral striatum. Subsequent tracing studies expanded on these observations by establishing that the PVT provides a dense projection to a continuum of striatal-like regions that include the nucleus accumbens and the extended amygdala.
View Article and Find Full Text PDFNervous system contributions to small cell lung cancer: Lessons from diverse oncological studies.
Biochim Biophys Acta Rev Cancer
February 2025
Thoracic Oncology Ward, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China; Department of Radiotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu, China; Laboratory of Clinical Cell Therapy, West China Hospital, Sichuan University, Chengdu, China. Electronic address:
The nervous system plays a vital role throughout the entire lifecycle and it may regulate the formation, development and metastasis of tumors. Small cell lung cancer is a typical neuroendocrine tumor, and it is naturally equipped with neurotropism. In this review, we firstly summarize current preclinical and clinical evidence to demonstrate the reciprocal crosstalk among the nervous system, tumor, and tumor microenvironment in various ways, including neurotransmitter-receptor pathways, innervations of nerve fibers, different types of synapse formation by neurons, astrocytes, and cancer cells, neoneurogenesis.
View Article and Find Full Text PDFUltrasonography for Assessment and Intervention With Botulinum Toxin Injection for Tremors.
Ann Rehabil Med
December 2024
Department of Rehabilitation Medicine, National Rehabilitation Center, Ministry of Health and Welfare, Seoul, Korea.
Objective: Tremors are caused by contractions of reciprocally innervated muscles. The role of ultrasound in diagnosing tremors has not yet been investigated, although it appears to be promising because it can visualize muscle movements. In the present study, we report four cases of tremor (Holmes' tremor, extremity tremor associated with palatal myoclonus, dystonic tremor, and tremor associated with dystonia), which were evaluated using ultrasound and treated with botulinum toxin injections.
View Article and Find Full Text PDFFrom Individual to Population: Circuit Organization of Pyramidal Tract and Intratelencephalic Neurons in Mouse Sensorimotor Cortex.
Research (Wash D C)
October 2024
State Key Laboratory of Digital Medical Engineering, School of Biomedical Engineering, Hainan University, Haikou, China.
The sensorimotor cortex participates in diverse functions with different reciprocally connected subregions and projection-defined pyramidal neuron types therein, while the fundamental organizational logic of its circuit elements at the single-cell level is still largely unclear. Here, using mouse Cre driver lines and high-resolution whole-brain imaging to selectively trace the axons and dendrites of cortical pyramidal tract (PT) and intratelencephalic (IT) neurons, we reconstructed the complete morphology of 1,023 pyramidal neurons and generated a projectome of 6 subregions within the sensorimotor cortex. Our morphological data revealed substantial hierarchical and layer differences in the axonal innervation patterns of pyramidal neurons.
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