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The type of diet consumed during prepuberty modulates plasma cholesterol, hepatic LXRα expression, and DNA methylation and hydroxymethylation during adulthood in male rats.
PLoS One
January 2025
Department of Nutritional Physiology, National Institute of Medical and Nutritional Sciences "Salvador Zubirán", Mexico City, Mexico.
Childhood obesity increases the risk of developing metabolic diseases in adulthood, since environmental stimuli during critical windows of development can impact on adult metabolic health. Studies demonstrating the effect of prepubertal diet on adult metabolic disease risk are still limited. We hypothesized that a prepubertal control diet (CD) protects the adult metabolic phenotype from diet-induced obesity (DIO), while a high-fat diet (HFD) would predispose to adult metabolic alterations.
View Article and Find Full Text PDFBaseline [F]FDG PET/CT radiomics for predicting interim efficacy in follicular lymphoma treated with first-line R-CHOP.
BMC Cancer
January 2025
PET/CT center, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, 127 Dongming Road, Zhengzhou, Henan, 450008, China.
Objective: To investigate the predictive value of machine learning-based PET/CT radiomics and clinical risk factors in predicting interim efficacy in patients with follicular lymphoma (FL).
Methods: This study retrospectively analyzed data from 97 patients with FL diagnosed via histopathological examination between July 2012 and November 2023. Lesion segmentation was performed using LIFEx software, and radiomics features were extracted through the uAI Research Portal (uRP) platform, including first-order features, shape features, and texture features.
Cellulose-based poly(ionic liquid)s: Correlations between degree of substitution and alkyl side chain length with conductive and morphological properties.
Int J Biol Macromol
January 2025
Department of Chemistry, Rutgers University, Camden, NJ, United States of America; Center for Computational and Integrative Biology, Rutgers University, Camden, NJ, United States of America. Electronic address:
Ion transport in solid polymer electrolytes is crucial for applications like energy conversion and storage, as well as carbon dioxide capture. However, most of the materials studied in this area are petroleum-based. Natural materials (biopolymers) have the potential to act as alternatives to petroleum-based products and, when derived with ionic liquid (IL) functionalities, present a sustainable alternative for conductive materials by offering tunable morphological, thermal, and mechanical properties.
View Article and Find Full Text PDFMotif distribution and DNA methylation underlie distinct Cdx2 binding during development and homeostasis.
Nat Commun
January 2025
Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Transcription factors guide tissue development by binding to developmental stage-specific targets and establishing an appropriate enhancer landscape. In turn, DNA and chromatin modifications direct the genomic binding of transcription factors. However, how transcription factors navigate chromatin features to selectively bind a small subset of all the possible genomic target loci remains poorly understood.
View Article and Find Full Text PDFRational design and analytical characterization of self-assembling poly(N-isopropylacrylamide) and poly(2-alkyl-2-oxazoline) hyaluronic acid copolymers.
Int J Pharm
January 2025
Novartis Pharma AG, GDD, TRD Biologics & CGT 4002 Basel, Switzerland.
In this study, we applied a systematic approach to establish an iterative workflow and to drive the chemical design of thermosensitive, in situ forming injectables as a function of the intended target product profile. Self-assembly, mechanical properties, physical state, and thermal transition behavior were assessed via nuclear magnetic resonance, oscillatory rheology, turbidimetry and visual inspection techniques. Thus, poly(N-isopropylacrylamide) (PNIPAM) and poly(2-alkyl-2-oxazoline)s (PAOx)s with LCSTs below body temperature were studied before and after grafting them onto azido-substituted hyaluronic acid (HA) via strain-promoted azide-alkyne cycloaddition (SPAAC).
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