Thymocytes of mice of different H-2 haplotypes are capable of releasing into culture medium an activity similar to that of stem cell inhibitory factor (SCIF) as regards suppressing action. All the test supernatants caused a decline in the number of hemopoietic colonies in the spleens of lethally irradiated (830 rad) syngeneic recipients. During study of the SCIF effect on bone marrow cells of different H-2 haplotypes, none of the strains appeared to be resistant to its action, which, probably, indicates the absence of genetic restriction of SCIF suppressive activity. Unlike migration inhibitory factor, SCIF does not appear to possess strain specificity.
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