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Self-Assembly of Homo Phenylalanine Oligopeptides: Role of Oligopeptide Chain Length.
Langmuir
January 2025
Biomimetic Materials and Tissue Engineering Laboratory, Department of Chemical Engineering, University of South Carolina, Columbia, South Carolina 29208, United States.
The self-assembly of phenylalanine (F)-based peptides is a critical area of research with potential implications for the development of advanced biomaterials and technologies. Previous studies indicate that homo-oligopeptides with F-X residues (X = 1 to 6) can self-assemble into diverse nano-microstructures, but the role of oligopeptide chain length on this process remains unclear. This review investigates the role of F-X chain length on self-assembly processes and morphologies, considering the effect of incubation conditions and the capping group at the N and/or C terminals.
View Article and Find Full Text PDFProtective Effects of Capsaicinoid Glucoside from Fresh Hot Peppers Against Hydrogen peroxide-induced Oxidative Stress in HepG2 Cells Through-dependent Signaling Pathway.
Plant Foods Hum Nutr
December 2024
College of Food Science and Technology, Huazhong Agricultural University, No. 1, Shuzishan Road, Wuhan, 8430070, China.
This study aimed to investigate the protective effect of a novel capsaicinoid glucoside (CG) against HO-induced oxidative stress in HepG2 cells and elucidate its underlying molecular mechanism. CG treatment significantly reduced HO-induced cell mortality and attenuated the production of lactate dehydrogenase and malondialdehyde in a dose-dependent manner. Moreover, CG drastically reduced the ROS levels 18.
View Article and Find Full Text PDFBoc-Protected Phenylalanine and Tryptophan-Based Dipeptides: A Broad Spectrum Anti-Bacterial Agent.
Biopolymers
January 2025
Department of Biotechnology, National Institute of Technology Durgapur, Durgapur, West Bengal, India.
Dipeptides were constructed using hydrophobic amino acid residues following AMP prediction. After that Boc-modification was performed on the screened peptides and finally Boc-Phe-Trp-OMe and Boc-Trp-Trp-OMe were synthesized. Even though no inhibition zones were observed in agar well diffusion assays, minimum inhibitory concentration (MIC) analysis revealed anti-bacterial activity against both Gram-positive and Gram-negative bacteria, with MIC ranging from 230 to 400 μg/mL.
View Article and Find Full Text PDFIdentification of novel antioxidant and anti-inflammatory peptides from bovine hemoglobin by computer simulation of enzymolysis, molecular docking and molecular dynamics.
Curr Res Food Sci
November 2024
Department of Animal Science, Chungbuk National University, Cheongju, 28644, Republic of Korea.
Unlabelled: Due to the structural diversity and complex mechanisms of action of bioactive peptides, screening for specific functional peptides is often challenging. To efficiently screen bioactive peptides with antioxidant and anti-inflammatory effects from bovine hemoglobin, we employed bioinformatics methods to perform virtual enzymatic hydrolysis using online tools and predicted the bioactivity, toxicity, and sensitization scores of the resulting peptides. Molecular docking and molecular dynamics simulations with Keap1 and TLR4 were subsequently conducted to screen for antioxidant and anti-inflammatory peptides.
View Article and Find Full Text PDFCoarse-Grained Simulation Study of the Association of Selected Dipeptides.
J Phys Chem B
December 2024
Faculty of Chemistry, University of Gdańsk, Fahrenheit Union of Universities in Gdańsk, Wita Stwosza 63, 80-308 Gdańsk, Poland.
The association of 55 dipeptides extracted from aggregation-prone regions of selected proteins was studied by means of multiplexed replica-exchange molecular dynamics simulations with the coarse-grained UNRES model of polypeptide chains. Each simulation was carried out with 320 dipeptide molecules in a periodic box at 0.24 mol/dm concentration, in the 260-370 K temperature range.
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