The process of inhibition growth zone formation due to diffusion of polyenic antibiotics into inoculated gel was studied. Variability of the zone size with time was traced as a continuation of the mathematical model of zone formation described earlier. Differences in the zone size variability are shown in case the drug inactivation level is so low that it may be neglected and in case the drug inactivation level is considered. An equation for determination of the maximum zone size for the latter case is presented. The experimental data qualitatively correlate with the theoretical propositions and may be explained within the frames of the mathematical models used.
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