We believe that the outline of a promising approach to the study of expert clinical problem-solving is emerging. This process involves collecting as verbal transcripts the thoughts of experienced clinicians engaged in simulated clinical tasks and analyzing these transcripts to formulate theories of problem-solving tactics and strategies. In turn, these theories are embodied in a computer program that simulates the problem-solving process. The computer program's response to fresh clinical problems can be compared with physician behavior in order to revise, refute, or confirm the problem-solving theories. A scientific understanding of the expert clinician's reasoning strategies could prove exceptionally useful in improving the way we teach and practice medicine and in developing practical computer aids for medical decision-making.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1016/0002-9343(82)90187-5 | DOI Listing |
Alzheimers Dement
December 2024
Fleni, Buenos Aires, Buenos Aires, Argentina.
Background: LatAm-FINGERS is a non-pharmacological multicenter randomized clinical trial aimed at preventing cognitive impairment. The intervention advocates for a lifestyle change based on diet, exercise, risk factor control, cognitive training, and socialization. However, the baseline assessment lacks a evaluation of the participants sociability before the intervention.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Acumen Pharmaceuticals, Charlottesville, VA, USA.
Background: Incorporation of the patient voice into drug development has been recognized as fundamental; recent legislation has addressed the importance of collecting patient experience data. Qualitative patient interviews conducted in tandem with clinical trials, often in later phases, are among the most common means of eliciting these data. To assess aspects of patient experience earlier in development, we conducted semi-structured qualitative interviews following participation in the phase 1 ACU-001 (INTERCEPT-AD) trial, a study evaluating the safety and tolerability of the Aβ oligomer-targeting monoclonal antibody ACU193, among a subset of participants with mild cognitive impairment (MCI) or mild Alzheimer's disease (AD) and their study partners.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Hadassah Hebrew University Medical Center, Jerusalem, Israel.
Background: The cognitive reserve (CR) theory seeks to explain the mismatch often reported between brain damage and its clinical expression. Unlike most previous studies that focused on individuals with memory deterioration before the diagnosis of Alzheimer's disease (AD), the present study examined the late stages of the disease. The study sought to confirm the hypothesis that patients with higher CR are diagnosed later and decline faster than those with lower CR because their brain pathology is more severe.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA.
Background: Black Americans (BAs), Hispanics/Latinos (H/Ls), and Africans (As) face a disproportionate burden of aging and Alzheimer's Disease and Related Dementias (AD/ADRD), coupled with underrepresentation in research. Further, researchers also report a lack of compliance on sensitive social determinants of health data for AD/ADRD research. For instance, the PRAPARE tool reports a low completion rate in community and clinical settings.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Centre Mémoire de Ressources et de Recherches, Pôle de Neurosciences Cliniques, CHU de Bordeaux, Bordeaux, France.
Aims: The Alzheimer Association (AA) has proposed new diagnostic criteria for Alzheimer's disease (AD) based on biomarkers coinciding with β-amyloidosis onset. However, there are concerns regarding the implications of these criteria.
Methods: We reviewed several perspectives, including disease definition, public health, philosophy, therapeutic, and diagnostic.
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!