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Significant Improvement in Digoxin Immunoassays Over Four Decades: Newer Assays are Less Affected by Interferences.
Ther Drug Monit
February 2023
Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas.
Background: Digitalis glycosides derived from foxglove plants have been used for medicinal purposes since the 16th century. Currently, digoxin derived from foxgloves is used clinically. Owing to the narrow therapeutic range, therapeutic drug monitoring is essential; however, digoxin immunoassays suffer from interference.
View Article and Find Full Text PDFEffect of purple grape juice on the pharmacokinetics of digoxin: Results of a food-drug interaction study .
Int J Clin Pharmacol Ther
February 2019
Objective: Digoxin is a glycosidic, cardiotonic plant extract with a narrow therapeutic window. The purpose of the study was to investigate the effects of purple grape juice on the pharmacokinetics of digoxin in rats.
Materials And Methods: A randomized, controlled, single- and multiple-dose study was conducted to evaluate the pharmacokinetic profiles of orally and intravenously administered digoxin.
In vivo effects of 17β-estradiol on cardiac Na(+)/K(+)-ATPase expression and activity in rat heart.
Mol Cell Endocrinol
May 2014
Institute of Nuclear Sciences Vinca, University of Belgrade, Laboratory of Radiobiology and Molecular Genetics, Mike Petrovica Alasa 12-14, 11000 Belgrade, Serbia. Electronic address:
In this study the in vivo effects of estradiol in regulating Na(+)/K(+)-ATPase function in rat heart was studied. Adult male Wistar rats were treated with estradiol (40μg/kg, i.p.
View Article and Find Full Text PDFIncreasing evidence for and regulation of a human placental endogenous digitalis-like factor.
Reprod Sci
April 2012
Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT, USA.
Endogenous digitalis-like factors (EDLFs) appear to be hypertensiogenic and increased in the serum and placenta of women with preeclampsia (PE), a complication of pregnancy. Digibind, an anti-digoxin antibody Fab fragment, reverses in vitro effects of EDLF and in vivo features of PE. We used Digibind in a radioimmunoassay to measure EDLF and compared this to a bio-functional assay of EDLF with good agreement.
View Article and Find Full Text PDFMultiple hemodynamic effects of endogenous hydrogen sulfide on central nervous system in rats.
Chin Med J (Engl)
November 2011
Department of Pathophysiology, Medical College of Wuhan University, Wuhan 430071, China.
Background: Endogenous hydrogen sulfide is a new neuromodulator which takes part in the regulation of central nervous system physiology and diseases. Whether endogenous hydrogen sulfide in the central nervous system regulates cardiovascular activity is not known. In the present study, we observed the hemodynamic changes of hydrogen sulfide or its precursor by intracerebroventricular injection, and investigate the possible roles of endogenous digitalis like factors and sympathetic activity in the regulation.
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