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The Improvement Effects of BC99 on Liver Function and Gut Microbiota of Long-Term Alcohol Drinkers: A Randomized Double-Blind Clinical Trial.
Nutrients
January 2025
College of Food and Bioengineering, Henan University of Science and Technology, Luoyang 471000, China.
Background/objectives: With the improvement of living standards, alcoholic liver disease caused by long-term drinking has been a common multiple disease. Probiotic interventions may help mitigate liver damage caused by alcohol intake, but the mechanisms need more investigation.
Methods: This study involved 70 long-term alcohol drinkers (18-65 years old, alcohol consumption ≥20 g/day, lasting for more than one year) who were randomly assigned to either the BC99 group or the placebo group.
Determination of Mechanical Properties of Blind Rivet Joints Using Numerical Simulations and Experimental Testing.
Materials (Basel)
January 2025
Faculty of Mechanical Engineering, University of West Bohemia, Univerzitni 2732/8, 301 00 Pilsen, Czech Republic.
This study explores the tensile performance of blind rivet joints in galvanized steel sheets, focusing on their behavior under shear and normal load conditions. Blind rivets are frequently used in structural applications due to their ease of installation and ability to be applied from one side, making them highly effective in industries like aerospace and automotive. Two types of DIN 7337-4.
View Article and Find Full Text PDFMultiple Sessions of Antimicrobial Photodynamic Therapy Improve Periodontal Outcomes in Patients with Down Syndrome: A 12-Month Randomized Clinical Trial.
Dent J (Basel)
January 2025
Discipline of Periodontics, Faculdade de Odontologia de Bauru, Universidade de São Paulo, São Paulo 05508-220, Brazil.
Individuals with Down syndrome (DS) often present with severe periodontal disease at a young age. Adjuvant treatments to scaling and root planing (SRP), such as antimicrobial photodynamic therapy (aPDT), may benefit this population. This study evaluated the effectiveness of aPDT as an adjunct to SRP in individuals with DS.
View Article and Find Full Text PDFPembrolizumab ± paricalcitol in metastatic pancreatic cancer postmaximal cytoreduction.
Oncologist
January 2025
HonorHealth Research Institute, Scottsdale, AZ, United States.
Lessons Learned: Intravenous paricalcitol did not improve the efficacy of pembrolizumab, likely related to the short half-life.
Background: Immunotherapy has limited benefit in the treatment of advanced pancreatic cancer with the tumor microenvironment playing a key role in immune resistance. In preclinical studies, vitamin D receptor (VDR) agonists have been shown to sensitize pancreatic tumors to PD-1 blockade.
The effects of seven-strain probiotic supplementation on cell adhesion molecules, oxidative stress, and antioxidant parameters in patients with traumatic brain injury: a randomized controlled clinical trial.
Br J Nutr
January 2025
Nutrition Research Center, Department of Biochemistry and Diet Therapy, Faculty of Nutrition & Food Sciences, Tabriz University of Medical Science, Tabriz, Iran.
The therapeutic effects of probiotics in patients with traumatic brain injury (TBI) remain unclear. This study aimed to investigate the effects of probiotic supplementation on cell adhesion molecules, oxidative stress, and antioxidant parameters in TBI patients. This randomized, double-blind, placebo-controlled trial included 46 TBI patients who were randomly assigned to receive either a probiotic supplement (n = 23) or a placebo (n = 23) for 14 days.
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