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[Identification and expression profiling of Dof transcription factor family in Aesculus chinensis].
Zhongguo Zhong Yao Za Zhi
November 2024
School of Pharmacy, Heilongjiang University of Chinese Medicine Harbin 150040, China Jiamusi College, Heilongjiang University of Chinese Medicine Jiamusi 154007, China.
Aesculus chinensis is an important medicinal and horticultural plant. Its dried mature seeds, known as "Suoluozi", are a well-known traditional Chinese medicine. Aescins are its main active components, possessing multiple pharmacological activities such as anti-inflammatory and anti-exudative effects.
View Article and Find Full Text PDFCombined in silico strategy for molecular mechanisms exploration of a series 3H-thiazolo[4,5-b]pyridin-2-ones exhibiting strong anti-exudative action through QSAR analysis, molecular docking and pharmacophore modelling is reported. GA-ML technique was used for QSAR models generation with 2D autocorrelation descriptors. One- and two-parameter regressions revealed that certain structural patterns or heteroatoms contribute mutually to the anti-exudative activity potentiation.
View Article and Find Full Text PDFAntidepressant activity of diterpene alkaloids of Aconitum baicalense Turcz.
Bull Exp Biol Med
August 2011
Laboratory of Phytopharmacology, Institute of Pharmacology, Siberian Division of Russian Academy of Medical Sciences, Tomsk, Russia.
Course treatment with diterpene alkaloids of Aconitum baicalense in mice reduced the time of immobilization in the tail suspension test and produced an antiexudative effect in mouse model of serotonin-induced edema. In the open field test, application of alkaloids did not change the total motor activity, orientation and exploratory behavior, and emotional reactions of animals. Experimental data suggest that diterpene alkaloids of Aconitum baicalensis exhibit antidepressant properties, possibly due to modulation of sensitivity to serotonin.
View Article and Find Full Text PDFAntinociceptive and anti-exudative synergism between dexketoprofen and tramadol in a model of inflammatory pain in mice.
Fundam Clin Pharmacol
June 2012
School of Medicine, Pharmacology Program, ICBM, Faculty of Medicine, Universidad de Chile, Clasificador 70.000, Santiago 7 Chile, Chile.
Preclinical studies have demonstrated antinociceptive synergism between dexketoprofen (DEX) and tramadol (TRM) in acute animal models of nociception. The aim of the present study was to investigate the type of interaction between DEX and TRM in a chronic musculoskeletal pain model in mice, which fairly replicates the characteristics of chronic osteoarticular pain in humans. Inflammation was induced by a subplantar injection of complete Freund's adjuvant (CFA) in male CF1 mice.
View Article and Find Full Text PDF[Early antiexudative response--OCT monitoring after intravitreal bevacizumab injection].
Ophthalmologe
June 2006
Augenklinik, Eberhard-Karls-Universität, Schleichstrasse 12, 72076 Tübingen.
VEGF is more potent than histamine by a factor of 50,000 for inducing increased vessel permeability. Already in the first few minutes, hydraulic conductivity and diffusive permeability are significantly increased, followed by a longer-lasting, marked leakage over 20 h. Specific inhibition of the angiogenic, vasoactive, and permeability-inducing protein VEGF is now possible by new drugs, one of which is the first available (off-label) treatment in Germany for routine clinical use (Avastin).
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