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Re-localization of a repeat-containing fungal effector by apoplastic protein Chitinase-like 1 blocks its toxicity.
Nat Commun
November 2024
State Key Laboratory of Crop Genetics & Germplasm Enhancement and Utilization, Nanjing Agricultural University, Nanjing, 210095, China.
A fungal effector that is toxic to plant cells was identified in Verticillium dahliae. The effector contains a non-canonical Common in several Fungal Extracellular Membrane proteins (CFEM) domain, a tandem repeat region consisting of four 14-amino acid repeats rich in proline, and a C-terminal region, thus is designated V. dahliae tetrapeptide repeat protein (VdTRP).
View Article and Find Full Text PDFRedox-Active Conopeptide Li520 Has Evolved to Catalyze Oxidative Folding of Conotoxins.
ACS Omega
September 2024
Department of Chemistry, School of Chemical Sciences, Central University of Karnataka, Kalaburagi 585367, Karnataka, India.
Article Synopsis
- The study investigates the evolution of the miniature conopeptide Li520, highlighting its disulfide isomerase activity by examining its structure and gene sequence.
- The synthesized peptides, including Li520 and its variants, show varying disulfide reduction potentials, indicating their effectiveness in protein folding and disulfide exchange reactions.
- Findings suggest that Li520's specific amino acid composition plays a crucial role in its functionality, and the peptide's evolution may aid in developing therapeutic peptides.
Peptides inhibiting the assembly of monomeric human l-lactate dehydrogenase into catalytically active homotetramer decrease the synthesis of lactate in cultured cells.
Protein Sci
October 2024
Department of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy.
The energetic metabolism of cancer cells relies on a substantial commitment of pyruvate to the catalytic action of lactate-generating dehydrogenases. This coupling mainly depends on lactate dehydrogenase A (LDH-A), which is overexpressed in different types of cancers, and therefore represents an appealing therapeutic target. Taking into account that the activity of LDHs is exclusively exerted by their tetrameric forms, it was recently shown that peptides perturbing the monomers-to-tetramer assembly inhibit human LDH-A (hLDH-A).
View Article and Find Full Text PDFSynthesis and mechanistic study of Aβ C-terminus domain derived tetrapeptides that inhibit Alzheimer's Aβ-aggregation-induced neurotoxicity.
Bioorg Med Chem Lett
November 2024
Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research, Sector 67, S.A.S. Nagar, Punjab 160062, India. Electronic address:
Amyloid plaque formation in the brain is mainly responsible for the onset of Alzheimer's disease (AD). Structure-based peptides have gained importance in recent years, and rational design of the peptide sequences for the prevention of Aβ-aggregation and related toxicity is imperative. In this study, we investigate the structural modification of tetrapeptides derived from the hydrophobic C-terminal region of Aβ "VVIA-NH" and its retro-sequence "AIVV-NH.
View Article and Find Full Text PDFSynthesis and Biological Evaluation of Amino Acid and Peptide Conjugates of 5-Bromovaleric Acid.
Med Chem
October 2024
Department of Pharmaceutical Chemistry, Shivalik College of Pharmacy, Nangal, 140126, Ropar, Punjab, India.
Background: Among various carboxylic acid derivatives, valeric acid or pentanoic acid is found to be widely distributed in nature. It is a straight-chain alkyl carboxylic acid containing five carbon atoms. Due to the therapeutic value of valeric acid, it is used as a versatile nucleus in the pharmaceutical field.
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