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Comparing the frequency, antifungal susceptibility, and enzymatic profiles of the oral fungal composition in patients with and without Alzheimer's disease admitted to a neurology clinic.
Front Cell Infect Microbiol
November 2024
Student research committee, Anzali International Medical Campus, Guilan University of Medical Sciences, Guilan, Iran.
Background: Studies have shown that changes in the frequency of oral microorganisms may play a key role in the development of Alzheimer's disease (AD). However, no research has been conducted on the oral fungal composition in AD-patients. The present study aimed to investigate the changes in the frequency of oral fungal composition, the antifungal susceptibility, and the enzymatic profiles of oral fungal composition in patients suffering from AD compared to non-AD individuals.
View Article and Find Full Text PDFFabrication of MnSnO intercalated TA-rGO modified sensor for selective electrochemical detection of chloramphenicol in real samples.
Food Chem
February 2025
School of Chemical Engineering, Yeungnam University, Gyeongsang, 38541, Republic of Korea.
Chloramphenicol (CAP), a potent antibiotic capable of inhibiting protein synthesis, presents significant challenges related to long-term dosing and its persistent leaching into the environment, raising concerns about environmental contamination and resistance development. To address this issue, we developed a reliable, low-cost, and biocompatible nanocomposite material comprising tannic acid (TA)-reduced graphene oxide (rGO) intercalated into manganese-doped tin oxide nanoparticles (MnSnO₂ NPs). The structural formation and catalytic activity of the MnSnO₂ NPs/TA-rGO nanocomposite were characterized using field emission-scanning electron microscopy (FE-SEM), high-resolution transmission electron microscopy (HR-TEM), X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FT-IR), Raman spectroscopy, X-ray photoelectron spectroscopy (XPS), and electrochemical techniques.
View Article and Find Full Text PDFA study on selected responses and immune structures of broiler chickens with experimental colibacillosis with or without florfenicol administration.
BMC Vet Res
August 2024
Department of Pathobiology, School of Veterinary Medicine, Shiraz University, Shiraz, Iran.
Background: Colibacillosis in broiler chickens is associated with economic loss and localized or systemic infection. Usually, the last resort is antibacterial therapy. Insight into the disease pathogenesis, host responses and plausible immunomodulatory effects of the antibacterials is important in choosing antibacterial agent and optimization of the treatment.
View Article and Find Full Text PDFDifferentiation activates mitochondrial OPA1 processing in myoblast cell lines.
Mitochondrion
September 2024
School of Integrative Biological & Chemical Sciences, The University of Texas Rio Grande Valley, United States; Medical Laboratory Sciences/Health & Biomedical Sciences, The University of Texas Rio Grande Valley, United States. Electronic address:
Mitochondrial optic atrophy-1 (OPA1) plays key roles in adapting mitochondrial structure to bioenergetic function. When transmembrane potential across the inner membrane (Δψ) is intact, long (L-OPA1) isoforms shape the inner membrane through membrane fusion and the formation of cristal junctions. When Δψ is lost, however, OPA1 is cleaved to short, inactive S-OPA1 isoforms by the OMA1 metalloprotease, disrupting mitochondrial structure and priming cellular stress responses such as apoptosis.
View Article and Find Full Text PDFHighly sensitive antibiotic sensing based on optical weak value amplification: A case study of chloramphenicol.
Food Chem
November 2024
Institute of Optical Imaging and Sensing, Shenzhen Key Laboratory for Minimal Invasive Medical Technologies, Shenzhen International Graduate School, Tsinghua University, Shenzhen City, Guangdong Province, China. Electronic address:
The public health concern of antibiotic residues in animal-origin food has been a long-standing issue. In this work, we present a novel method for antibiotic detection, leveraging optical weak value amplification and harnessing an indirect competitive inhibition assay, which significantly boosts the system's sensitivity in identifying small molecule antibiotics. We chose chloramphenicol as a model compound and mixed it with chloramphenicol-bovine serum albumin conjugates to bind to the chloramphenicol antibody competitively.
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