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SLC29A1 and SLC29A2 are human nicotinamide cell membrane transporters.
Nat Commun
January 2025
College of Pharmaceutical Sciences, National Key Laboratory of Advanced Drug Delivery and Release Systems, Zhejiang University, Hangzhou, China.
Nicotinamide (NAM), a main precursor of NAD+, is essential for cellular fuel respiration, energy production, and other cellular processes. Transporters for other precursors of NAD+ such as nicotinic acid and nicotinamide mononucleotide (NMN) have been identified, but the cellular transporter of nicotinamide has not been elucidated. Here, we demonstrate that equilibrative nucleoside transporter 1 and 2 (ENT1 and 2, encoded by SLC29A1 and 2) drive cellular nicotinamide uptake and establish nicotinamide metabolism homeostasis.
View Article and Find Full Text PDFReal-world application of physiologically based pharmacokinetic models in drug discovery.
Drug Metab Dispos
January 2025
Simcyp Division, Certara UK, Ltd, Princeton, New Jersey. Electronic address:
The utility of physiologically based pharmacokinetic (PBPK) models in support of drug development has been well documented. During the discovery stage, PBPK modeling has increasingly been applied for early risk assessment, prediction of human dose, toxicokinetic dose projection, and early formulation assessment. Previous review articles have proposed model-building and application strategies for PBPK-based first-in-human predictions with comprehensive descriptions of the individual components of PBPK models.
View Article and Find Full Text PDFMetabolic and molecular Characterization, following dietary exposure to DINCH, Reveals new Implications for its role as a Metabolism-Disrupting chemical.
Environ Int
January 2025
Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Centre München at the University of Leipzig Germany; Department of Endocrinology Nephrology Rheumatology University Hospital Leipzig Medical Research Center Leipzig Germany.
Plastic materials are ubiquitous, leading to constant human exposure to plastic additives such as plasticizers. There is growing evidence that plasticizers may contribute to obesity due to their disruptive effects on metabolism. Alternatives like diisononylcyclohexane-1,2-dicarboxylate (DINCH) are replacing traditional phthalates such as di-(2-ethylhexyl) phthalate (DEHP), which are now banned due to their proven harmful health effects.
View Article and Find Full Text PDFModulation of plant carbon and nitrogen metabolism by novel actinobacteria Rhodospirillum sp. to combat galaxolide toxicity in barley and maize plants.
Plant Physiol Biochem
December 2024
Botany and Microbiology Department, Faculty of Science, Beni-Suef University, Beni‒Suef, Egypt; Integrated Molecular Plant Physiology Research, Department of Biology, University of Antwerp, Antwerp, Belgium.
The phytotoxic effect of cosmetics such as galaxolide (HHCB) has been investigated, however, their metabolic basis of this impact is still obscure. Thus, we investigated the effect of HHCB on the biomass accumulation, photosynthesis, primary and secondary metabolites in two species from different functional groups i.e.
View Article and Find Full Text PDFIsolation of Natural Products from Marine Invertebrates.
Methods Mol Biol
January 2025
Marine Natural Products Chemistry Laboratory, Korea Institute of Ocean Science and Technology, Busan, Republic of Korea.
Marine invertebrates such as sponges, cnidarians, bryozoans, and tunicates are considered to be prolific sources of novel biologically active natural products. Specimens from these organisms are composed of soft tissues with a high water and inorganic salt content compared to those from terrestrial counterparts. In addition, some of the secondary metabolites from these organisms tend to be more polar than those of terrestrial.
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