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Reevaluating vitamin C in sepsis and septic shock: a potential benefit in severe cases?
Front Med (Lausanne)
October 2024
College of Pharmacy, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.
Vitamin C (Ascorbic acid) has evolved as an emergent co-intervention for sepsis and septic shock patients. Multiple studies discussed the pathophysiological value of vitamin C to reserve endothelial functionality and improve microcirculatory flow in these patients. Nevertheless, most randomized clinical trials failed to show the clinical impact of adding vitamin C to sepsis and septic shock.
View Article and Find Full Text PDFComparison of contrast-enhanced ultrasound imaging (CEUS) and super-resolution ultrasound (SRU) for the quantification of ischaemia flow redistribution: a theoretical study.
Phys Med Biol
November 2024
School of Engineering & Physical Sciences, Heriot-Watt University, Edinburgh EH14 4AS, United Kingdom.
Article Synopsis
- The study investigates how microcirculation alterations can indicate vascular pathologies, particularly through methods like contrast enhanced ultrasound (CEUS) and super-resolution ultrasound (SRU) imaging.
- CEUS showed limitations in accurately measuring blood flow in microvascular areas due to interference from larger vessels and varying degrees of blood flow redistribution, which affected correlation with actual flow rates.
- In contrast, SRU demonstrated high accuracy in depicting blood vessel structures and dynamics, achieving over 91% correspondence with ground truth measurements, suggesting it may be a more effective tool for studying subtle flow changes caused by ischaemia.
Comparative Analysis of Heart Rate Variability and Arterial Stiffness in Elite Male Athletes after COVID-19.
J Clin Med
October 2024
EA 3300, Exercise Physiology and Rehabilitation Laboratory, Sport Sciences Department, Picardie Jules Verne University, F-80025 Amiens, France.
Article Synopsis
- * Results indicated that post-COVID-19 athletes had higher lean mass and better lung capacity, but similar heart rate variability and blood pressure compared to controls.
- * Overall, elite athletes showed resilience in cardiovascular health after COVID-19, yet the study underscores the need for ongoing monitoring of their cardiovascular function.
Role of Heavy Water in Modified University of Wisconsin Solution for Extended Cold Storage of Rat Liver.
Transplant Proc
October 2024
Gastroenterological Surgery 1, Graduate School of Medicine, Hokkaido University, Sapporo, Japan; Department of Transplant Surgery, Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
To resolve the critical donor shortage worldwide, enlarging the potential donor pool to include expanded criteria donors is necessary. Despite numerous attempts to establish new preservation solutions, no dramatic innovation has occurred since University of Wisconsin (UW) solution displaced Euro Collins' solution; UW solution remains the global gold standard. We previously developed a heavy water (DO)-containing organ storage solution, Dsol, which is effective for livers subjected to extended cold storage (CS), and reported its effectiveness.
View Article and Find Full Text PDFMicrocirculatory disturbance in acute liver injury is triggered by IFNγ-CD40 axis.
J Inflamm (Lond)
June 2024
Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
Background: Acute liver failure (ALF) is a life-threatening disorder that progresses from self-limiting acute liver injury (ALI). Microcirculatory disturbance characterized by sinusoidal hypercoagulation and subsequent massive hypoxic hepatocyte damage have been proposed to be the mechanism by which ALI deteriorates to ALF; however, the precise molecular pathway of the sinusoidal hypercoagulation remains unknown. Here, we analyzed ALI patients and mice models to uncover the pathogenesis of ALI with microcirculatory disturbance.
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