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Correlation of ACE gene polymorphisms and platelet parameters with morning peak blood pressure in hypertensive patients.
Am J Transl Res
December 2024
Department of Cardiology, Wujin Hospital Affiliated with Jiangsu University Changzhou 213004, Jiangsu, China.
Objective: To analyze the relationship between platelet parameters, morning peak blood pressure (MPBP) in hypertensive patients, and angiotensin-converting enzyme (ACE) gene polymorphisms.
Methods: This study included 245 primary hypertensive patients treated between February 2019 and February 2022, who were divided into two groups based on MPBP status: 144 patients with MPBP and 101 without MPBP. Baseline data and early morning fasting blood samples from the antecubital vein were collected.
Clinical Pharmacokinetics of Psilocin After Psilocybin Administration: A Systematic Review and Post-Hoc Analysis.
Clin Pharmacokinet
January 2025
Leiden Academic Centre for Drug Research (LACDR), Leiden University, Leiden, The Netherlands.
Background And Objective: Psilocybin is currently being extensively studied as a potential therapeutic agent for multiple psychiatric disorders. Here, a systematic literature review of all published pharmacokinetic data on the pharmacologically active metabolite of psilocybin, psilocin, is presented.
Methods: The review includes clinical studies that reported pharmacokinetic data and/or parameters after psilocybin administration in humans.
Oral Administration of [F]MC225 for Quantification of P-glycoprotein Function: A Feasibility Study.
Mol Imaging Biol
January 2025
Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Purpose: This preclinical study explored the feasibility of assessing P-glycoprotein (P-gp) function in both brain and gastrointestinal (GI) tract of rats using positron emission tomography (PET) following oral administration of [F]MC225. Different oral administration protocols were evaluated, and radioactivity uptake was compared with uptake following intravenous administration.
Procedures: Twelve male Wistar rats were divided into four groups and subjected to intravenous or oral [F]MC225 administration protocols: G (intravenous route), G (oral administration without fasting), G (oral administration with fasting), and G (oral administration with fasting following administration of the P-gp inhibitor tariquidar).
Population pharmacokinetics of cannabidiol and the impact of food and formulation on systemic exposure in children with drug-resistant developmental and epileptic encephalopathies.
Epilepsia
January 2025
Unit of Innovative Treatments, Hospital de Pediatría JP Garrahan, Buenos Aires, Argentina.
Objective: Identifying factors influencing cannabidiol (CBD) exposure can optimize treatment efficacy and safety. We aimed to describe the population pharmacokinetics of CBD in children with drug-resistant developmental and epileptic encephalopathies (DEEs) and assess the influence of environmental, pharmacological, and clinical characteristics on CBD systemic exposure.
Methods: Data from two pharmacokinetic studies of patients aged 2-18 years with DEEs were included (N = 48 patients).
Long-term fasting induces a remodelling of fatty acid composition in erythrocyte membranes.
Eur J Clin Invest
January 2025
Buchinger Wilhelmi Clinic, Überlingen, Germany.
Introduction: Long-term fasting (LF) activates an adaptative response to switch metabolic fuels from food glucose to lipids stored in adipose tissues. The increase in free fatty acid (FFA) oxidation during fasting triggers health benefits. We questioned if the changes in lipid metabolism during LF could affect lipids in cell membranes in humans.
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