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Polyester-based microdisc systems for sustained release of neuroprotective phosphine-borane complexes.
Pharm Dev Technol
November 2018
a Department of Ophthalmology and Visual Sciences , University of Wisconsin School of Medicine and Public Health, Madison , WI , USA.
Phosphine-borane complexes are recently developed redox-active drugs that are neuroprotective in models of optic nerve injury and radioprotective in endothelial cells. However, a single dose of these compounds is short-lived, necessitating the development of sustained-release formulations of these novel molecules. We screened a library of biodegradable co- and non-block polyester polymer systems for release of incorporated phosphine-borane complexes to evaluate them as drug delivery systems for use in chronic disease.
View Article and Find Full Text PDFThe SYNERGY biodegradable polymer everolimus eluting coronary stent: Porcine vascular compatibility and polymer safety study.
Catheter Cardiovasc Interv
November 2015
Boston Scientific Corporation, Marlborough, Massachusetts.
Aims: SYNERGY is a novel platinum chromium alloy stent that delivers abluminal everolimus from an ultrathin poly-lactide-co-glycide (PLGA) biodegradable polymer. This study evaluated the in vivo degradation of the polymer coating, everolimus release time course, and vascular compatibility of the SYNERGY stent.
Methods And Results: SYNERGY stents were implanted in arteries of domestic swine.
Telmisartan and metabolic syndrome after heart transplantation.
Clin Transplant
September 2010
Heart Failure and Transplant Department, National Institute of Cardiovascular Disease, Bratislava, Slovakia.
Introduction: Metabolic syndrome (MS) is a cardiovascular risk predictor. Prevalence of MS after heart transplantation (HTx) is high. Recent data suggest a positive metabolic effect of telmisartan.
View Article and Find Full Text PDFHydroxyethyl starch-induced itch: relevance of light microscopic analysis of semi-thin sections and electron microscopy.
J Dtsch Dermatol Ges
March 2007
Clinic and Polyclinic for Dermatology and Allergology, Ludwig-Maximilian University, Munich, Germany.
Background: Hydroxyethyl starch (HES) is widely used as a plasma substitute for improving microcirculation. A major side effect of HES is severe pruritus caused by HES deposits in the skin. Since specific changes are difficult to see in paraffin sections, electron microscopy is the golden standard technique in the diagnosis of HES-induced skin disease.
View Article and Find Full Text PDF[Prevention of venous thromboembolism in psychiatry].
Vnitr Lek
March 2006
I. interní klinika Lékarské fakulty UK a FN, Hradec Králové.
The hospitalized patients of the psychiatric wards represent a risk group for the development of venous thromboembolism. Apart from sedative administration, total movement reduction, bad life style and daily routine and increased body weight, there is negative impact of dehydration, prolonged hospitalization and sometimes immobilisation in consequence of mechanical restraints. A large amount of patients are treated with antipsychotics that have a series of adverse effects.
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