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Portable six-channel laser speckle system for simultaneous measurement of cerebral blood flow and volume with potential applications in characterization of brain injury.
Neurophotonics
January 2025
California Institute of Technology, Department of Electrical Engineering, Pasadena, California, United States.
Significance: Cerebral blood flow (CBF) and cerebral blood volume (CBV) are key metrics for regional cerebrovascular monitoring. Simultaneous, non-invasive measurement of CBF and CBV at different brain locations would advance cerebrovascular monitoring and pave the way for brain injury detection as current brain injury diagnostic methods are often constrained by high costs, limited sensitivity, and reliance on subjective symptom reporting.
Aim: We aim to develop a multi-channel non-invasive optical system for measuring CBF and CBV at different regions of the brain simultaneously with a cost-effective, reliable, and scalable system capable of detecting potential differences in CBF and CBV across different regions of the brain.
In regional cerebrovascular monitoring, cerebral blood flow (CBF) and cerebral blood volume (CBV) are key metrics. Simultaneous, non-invasive measurement of CBF and CBV at different brain locations would advance cerebrovascular monitoring and pave the way for brain injury detection, as current brain injury diagnostic methods are often constrained by high costs, limited sensitivity, and reliance on subjective symptom reporting. This study's aim is to develop a multi-channel non-invasive optical system for measuring CBF and CBV at different regions of the brain simultaneously with a cost-effective, reliable, and scalable system capable of detecting potential differences in CBF and CBV across different regions of the brain.
View Article and Find Full Text PDFReview of Photodetectors for Space Lidars.
Sensors (Basel)
October 2024
Planetary Geology, Geophysics and Geochemistry Laboratory, Solar System Exploration Division, NASA Goddard Space Flight Center, Greenbelt, MD 20771, USA.
Photodetectors play a critical role in space lidars designed for scientific investigations from orbit around planetary bodies. The detectors must be highly sensitive due to the long range of measurements and tight constraints on the size, weight, and power of the instrument. The detectors must also be space radiation tolerant over multi-year mission lifetimes with no significant performance degradation.
View Article and Find Full Text PDFPrecise Regulation of the Reverse Intersystem Crossing Pathway by Hybridized Long-Short Axis Strategy for High-Performance Multi-Resonance TADF Emitters.
Angew Chem Int Ed Engl
January 2025
Jilin University, State Key Laboratory of Supramolecular Structure and Materials, Department of Chemistry, Changchun, 130012, P. R. China.
Multi-resonance thermally activated delayed fluorescence (MR-TADF) molecules have experienced great success in organic light-emitting diodes (OLEDs) owing to their outstanding quantum efficiencies and narrow full width at half-maximums (FWHMs). However, the reverse intersystem crossing (RISC) rates of MR-TADF emitters are usually small, which will lead to relatively long triplet exciton lifetime and severe efficiency roll-off. Here, we report an effective molecular design strategy to introduce multichannel RISC pathways and thus increase RISC rates without compromising the color fidelity and emission efficiency by the "hybridized long-short axis (HLSA)" strategy.
View Article and Find Full Text PDFEnhancement of NIR-II Emission of Er by Doping Fe in Double Perovskites: Multimode Luminescence for Versatile Optoelectronic Applications.
Angew Chem Int Ed Engl
January 2025
State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin, 130022, P. R. China.
Erbium ions are commonly used to extend the photoelectric properties of metal halide perovskites from visible to near-infrared range. However, achieving high-efficiency multimode luminescence in a single system is difficult due to the weak absorption associated with forbidden 4f-4f transitions. In this study, a unique strategy is proposed to adjust multimode luminescence and enhance the second near-infrared region (NIR-II) emission in CsNaBiCl by incorporating Fe ions.
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