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Exploring the handedness-breast cancer nexus: a comprehensive analysis via systematic review, meta-analysis, and Mendelian randomization.
Ther Adv Med Oncol
December 2024
Department of Anatomy and Department of Biomedical Informatics, Pusan National University, 49 Busandaehak-ro, Yangsan 50612, Republic of Korea.
Background: Given the widespread prevalence of breast cancer as a global malignancy, there is a compelling need to delve into its risk determinants.
Objective: This study aims to investigate the potential relationship between indicators of left-handedness and breast cancer, employing systematic review, meta-analysis, and Mendelian randomization methods.
Design: Systematic review and meta-analysis.
Does the Surgeon's Handedness Affect the Complications Rate in the Inframammary Approach Breast Augmentation?
Aesthetic Plast Surg
September 2024
Department of Plastic Surgery, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
Background: Humans show a preference for left or right handedness in most cases. For this reason, surgeons might find it more difficult to operate on the "nondominant breast", i.e.
View Article and Find Full Text PDFDoes Laterality in Breast Cancer still have the Importance to be Studied? A Meta-analysis of Patients with Breast Cancer.
Curr Med Chem
July 2024
School of Chinese Medicine, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
Background: Breast cancer (BC) is one of the most common cancers in the world. Studies show that left-sided BC in pre and post-menopausal women leads to double the risk of worse morbidity and mortality and the reasons are uncertain. Finding the relationship between BC laterality and other possible risk factors can be advantageous for the prognosis of BC.
View Article and Find Full Text PDFAnalysis of the Risk Factors of Breast Cancer-Related Lymphedema and Construction and Evaluation of a Prediction Model.
Lymphat Res Biol
December 2023
Department of Rehabilitation, Hebei Medical University, Heibei, China.
The occurrence of breast cancer-related lymphedema (BCRL) in postoperative breast cancer survivors is described and the independent risk factors of BCRL are analyzed. A BCRL nomogram prediction model is constructed, and its effectiveness is evaluated to screen out high-risk patients with BCRL. A univariate analysis was carried out to determine the risk factors possibly related to BCRL, and a logistic regression analysis was utilized to determine the independent risk factors related to BCRL.
View Article and Find Full Text PDFThe Yin and Yang of Breast Cancer: Ion Channels as Determinants of Left-Right Functional Differences.
Int J Mol Sci
July 2023
Institute of Histology and Embryology, National Council of Scientific and Technological Research (CONICET), Parque General San Martin, Mendoza 5500, Argentina.
Breast cancer is a complex and heterogeneous disease that displays diverse molecular subtypes and clinical outcomes. Although it is known that the location of tumors can affect their biological behavior, the underlying mechanisms are not fully understood. In our previous study, we found a differential methylation profile and membrane potential between left (L)- and right (R)-sided breast tumors.
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