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NEDD4-Mediated GSNOR Degradation Aggravates Cardiac Hypertrophy and Dysfunction.
Circ Res
January 2025
Key Laboratory of Drug Targets and Translational Medicine for Cardio-cerebrovascular Diseases, Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Jiangsu, China (X.T., X.L., X.S., Y. Zhang, Y. Zu, Q.F., L.H., S.S., F.C., L.X., Y.J.).
Background: The decrease in S-nitrosoglutathione reductase (GSNOR) leads to an elevation of S-nitrosylation, thereby exacerbating the progression of cardiomyopathy in response to hemodynamic stress. However, the mechanisms under GSNOR decrease remain unclear. Here, we identify NEDD4 (neuronal precursor cell expressed developmentally downregulated 4) as a novel molecule that plays a crucial role in the pathogenesis of pressure overload-induced cardiac hypertrophy, by modulating GSNOR levels, thereby demonstrating significant therapeutic potential.
View Article and Find Full Text PDFSe-methylselenocysteine inhibits inflammatory response in an LPS-stimulated chicken HD11 macrophage-like cell model through the NFKB2 pathway.
Front Vet Sci
January 2025
College of Animal Science and Technology, Yangtze University, Jingzhou, China.
Among the various sources of selenium supplementations, the Se-methylselenocysteine (SeMC) is a natural organic selenium compound that has been demonstrated to have multiple advantages in terms of metabolism efficiency and biosafety in animals. Nevertheless, the genome-wide impact of SeMC on gene transcription remains to be elucidated. In this study, we employed an LPS-stimulated chicken HD11 macrophage-like cell model to identify the principal transcription factors involved in transcriptome regulation responsible for SeMC treatment.
View Article and Find Full Text PDFWhich type of feedback-Positive or negative- reinforces decision recall? An EEG study.
Front Syst Neurosci
January 2025
International research center for Cognitive Applied Neuroscience (IrcCAN), Università Cattolica del Sacro Cuore, Milan, Italy.
This study examines the impact of positive and negative feedback on recall of past decisions, focusing on behavioral performance and electrophysiological (EEG) responses. Participants completed a decision-making task involving 10 real-life scenarios, each followed by immediate positive or negative feedback. In a recall phase, participants' accuracy (ACC), errors (ERRs), and response times (RTs) were recorded alongside EEG data to analyze brain activity patterns related to recall.
View Article and Find Full Text PDFMany cellular functions depend on the physical properties of the cell's environment. Many bacteria have different types of surface appendages to enable adhesion and motion on various surfaces. is a social soil bacterium with two distinctly regulated modes of surface motility, termed the social motility mode, driven by type IV pili, and the adventurous motility mode, based on focal adhesion complexes.
View Article and Find Full Text PDFThreat to the predator suppresses defence of its prey.
R Soc Open Sci
January 2025
Department of Hydrobiology, Institute of Ecology, Faculty of Biology, University of Warsaw, Żwirki i Wigury 101, Warsaw 02-089, Poland.
Many studies have shown that prey can optimize their defence mechanisms based on cues indicating predator presence and pressure. However, little is known about whether prey can assess the actual threat by considering both predator density and the motivational state of cannibalistic predators, which can be influenced by threats from higher order predators. We conducted laboratory experiments to test the hypothesis that high predator density, combined with chemical cues indicating predator stress (e.
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