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Improved Survival and Symptom Relief Following Palliative Cerebrospinal Fluid Diversion for Leptomeningeal Disease from Brain Cancers: A Case Series and Systematic Review.
Cancers (Basel)
January 2025
Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA 94304, USA.
Background: Leptomeningeal disease (LMD) from cancer indicates advanced cancer and can lead to obstructive hydrocephalus, for which palliative cerebrospinal fluid (CSF) diversion may be indicated to alleviate symptoms. We investigated surgical outcomes for hydrocephalus for adult patients with LMD and conducted a systematic review on pediatric and adult cases.
Methods: We analyzed outcomes from a 10-year period of patients with neoplastic LMD, obstructive hydrocephalus, and documented date of death.
Breaking boundaries: A rare case of glioblastoma with uncommon extraneural metastases: A case report and literature review.
Brain Spine
October 2024
Department of Clinical Medicine, University of Bergen Faculty of Medicine and Dentistry, Bergen, Norway.
Introduction: Extraneural metastases (ENM) from glioblastoma (GBM) remain extremely rare with only a scarce number of cases described in the literature. The lack of cases leads to no consensus on the optimal treatment and follow-up of these patients.
Research Question: Do patient or tumor characteristics describe risk factors for ENM in GBM patients, and is it possible to identify mechanisms of action?
Material And Methods: This study presents a 55-year-old man with diagnosed GBM who was referred to a CT due to reduced general condition and mild back pain which revealed extensive systemic metastases.
Clinical and Imaging Features of Head and Neck Metastasis of High-Grade Glioma: A Single-Center Case Series.
AJNR Am J Neuroradiol
January 2025
Departments of Neuroradiology and Imaging Physics (D.S.), The University of Texas MD Anderson Cancer Center, Houston, Texas.
High-grade gliomas are the most frequent primary brain tumors, yet extraneural metastasis is exceedingly rare. This is in part secondary to the relatively poor survival of these patients and likely the shielding effect of the blood-brain barrier. Given the rarity of extraneural metastasis, the pathophysiology and imaging appearance of extraneural metastasis is under-reported and poorly understood.
View Article and Find Full Text PDFPseudolipoblastic Perineuroma: A Rare Histologi̇c Subtype.
Am J Dermatopathol
December 2024
U.O.C. Dermatologia, IRCCS Azienda Ospedaliero-Universitaria di Bologna Italia, Bologna, Italy ; and.
Pseudolipoblastic perineurioma is a very uncommon variant of extraneural perineurioma, with only a limited number of cases documented in the medical literature. The most remarkable histopathologic characteristic is the existence of vacuolated cells that closely resemble lipoblasts; besides the presence of small, spindle shaped, or epithelioid perineurial cells. In this study, we present another case of pseudolipoblastic perineurioma, predominantly characterized by the presence of vacuolated "pseudolipoblastic" cells.
View Article and Find Full Text PDFSpinal Diffuse Midline Glioma -Altered: Report of a Rare Tumor with Extracranial Skeletal Metastases and Review of Literature.
Int J Surg Pathol
October 2024
Department of Pathology, Tata Memorial Hospital and ACTREC, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, India.
Article Synopsis
- * These tumors are located in critical areas of the brain and spinal cord, making surgical intervention difficult, and they typically present with a specific set of symptoms.
- * A case of a 17-year-old girl with spinal diffuse midline glioma showed unusual bone metastases, highlighting the need for early diagnosis and personalized treatment plans, as well as the importance of further research into the tumor's molecular characteristics.
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