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Investigating the resilience of kidneys in rats exposed to chronic partial sleep deprivation and circadian rhythm disruption as disruptive interventions.
Neurobiol Sleep Circadian Rhythms
May 2025
Cellular and Molecular Research Center, Department of Anatomical Sciences, Birjand University of Medical Sciences, Birjand, Iran.
Sleep is a vital biological function that significantly influences overall health. While sleep deprivation (SD) and circadian rhythm disruption are known to negatively impact various organs, their specific effects on kidney function remain understudied. This study aimed to investigate the impact of chronic partial sleep deprivation and circadian rhythm disruption on renal function in rats, providing insights into the relationship between sleep disturbances and kidney health.
View Article and Find Full Text PDFChronic sleep deprivation disturbs energy balance modulated by suprachiasmatic nucleus efferents in mice.
BMC Biol
December 2024
Key Laboratory of Environmental Stress and Chronic Disease Control & Prevention Ministry of Education, China Medical University, No. 77 Puhe Road, Shenyang North New Area, Shenyang, Liaoning, 110122, People's Republic of China.
Background: Epidemiologic researches show that short sleep duration may affect feeding behaviors resulting in higher energy intake and increased risk of obesity, but the further mechanisms that can interpret the causality remain unclear. The circadian rhythm is fine-tuned by the suprachiasmatic nucleus (SCN) as the master clock, which is essential for driving rhythms in food intake and energy metabolism through neuronal projections to the arcuate nucleus (ARC) and paraventricular nucleus (PVN).
Results: We showed that chronic SD-induced aberrant expressions of AgRP/NPY and POMC attributed to compromised JAK/STAT3 signals and reduced energy expenditure in the mice, which can be rescued with AAV-genetic overexpression of BMAL1 into SCN.
Struggling to afford medicines: a qualitative exploration of the experiences of participants in the FreeMeds study.
J Prim Health Care
December 2024
Health Services Research Centre, Victoria University of Wellington, PO Box 600, Wellington, New Zealand.
Introduction Existing research has established that some people struggle with prescription charges. This paper reports on the experiences of a sub-sample of people who participated in the FreeMeds study (a randomised controlled trial of prescription charges) about their problems paying for medicines. Aim The aim of this study was to explore participants' previous experiences with paying for medicines, and the impact of receiving free medicines through the Free Meds study.
View Article and Find Full Text PDFImpact of exercise and fasting on mitochondrial regulators in human muscle.
Transl Exerc Biomed
September 2024
School of Kinesiology and Health Studies, Queen's University, Kingston, ON, Canada.
Objectives: To investigate the impact of acute energetic stress (acute HIIE and fasting) on , , , , and in human skeletal muscle.
Methods: The current study performed secondary analyses using muscle biopsy samples from two previously published studies: study 1) leg muscle biopsies from nine men and eight women were obtained pre and 3 h following acute high-intensity interval cycling exercise (HIIE); study 2) leg muscle biopsies were obtained from nine men pre-, during, and post-an 8 h fast with or without 2 h of arm ergometer exercise. RT-PCR was performed on samples from each study to determine the mRNA expression of , , , , and .
Short Sleep Duration and Skipping Main Meals among University Students.
Sleep Sci
December 2024
Department of Food and Nutrition, College of Nutrition, Universidade Federal de Mato Grosso, Cuiabá, MT, Brazil.
Admission to university influences lifestyle behaviors and is marked by a daily routine of accumulation of activities that can interfere with sleep duration, affecting food choices and meal consumption habits throughout the day. To analyze the association between short sleep duration and skipping main meals among university students. We conducted a cross-sectional study with 1,608 university students aged between 16 and 25 years, who were enrolled in full-time undergraduate courses at a public university in the Midwestern region of Brazil.
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