Motor performance and cognitive function were examined in depressed patients and controls. Increasing severity of depression was strongly associated with decrements in performance in both motor and memory tasks. Greatest depression-related impairment was found on those cognitive and motor tasks that required sustained effort. We discuss these results in terms of a generalized deficit in the central motivational state of depressed individuals.
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http://dx.doi.org/10.1001/archpsyc.1982.04290050061012 | DOI Listing |
Gerontologist
January 2025
U.S. Department of Veterans Affairs National Center for PTSD, VA Connecticut Healthcare System, West Haven, CT, USA.
Background And Objectives: Insomnia symptoms are more prevalent in older age and may be impacted by negative perceptions of aging; however, more research is needed. The present study characterizes the relationship between negative aging stereotypes and clinical insomnia symptoms in a nationally representative sample of older United States (U.S.
View Article and Find Full Text PDFRev Sci Instrum
January 2025
Bennu Climate, Inc. and Symbolic Systems Program, Stanford University, Stanford, California 94305, USA.
The Linac Coherent Light Source (LCLS) is the world's first x-ray free electron laser. It is a scientific user facility operated by the SLAC National Accelerator Laboratory, at Stanford, for the U.S.
View Article and Find Full Text PDFMol Neurodegener
January 2025
Department of Radiology and Imaging Sciences, Center for Neuroimaging, Indiana University School of Medicine, Indianapolis, IN, USA.
Alzheimer's disease (AD) is a debilitating neurodegenerative disease that is marked by profound neurovascular dysfunction and significant cell-specific alterations in the brain vasculature. Recent advances in high throughput single-cell transcriptomics technology have enabled the study of the human brain vasculature at an unprecedented depth. Additionally, the understudied niche of cerebrovascular cells, such as endothelial and mural cells, and their subtypes have been scrutinized for understanding cellular and transcriptional heterogeneity in AD.
View Article and Find Full Text PDFBMC Psychol
January 2025
School of Mental Health and Psychological Sciences, Anhui Medical University, Hefei, China.
Background: Major decision-making self-efficacy (MDMSE) is an important indicator of students' ability to make effective decisions in specialty selection. It has implications for students' personal growth and career counselling interventions. While the previous MDMSES has been widely used in the context of China's New College Entrance Examination reform, the increased choice of majors and advancement of career planning necessitate a new scale to assess high school students' MDMSE levels.
View Article and Find Full Text PDFJ Control Release
January 2025
Paris Brain Institute, ICM, Inserm U1127, CNRS UMR 7225, Sorbonne University, 75013 Paris, France.
Unlabelled: Blood-brain barrier opening with ultrasound can potentiate drug efficacy in the treatment of brain pathologies and also provides therapeutic effects on its own. It is an innovative tool to transiently, repeatedly and safely open the barrier, with studies showing beneficial effects in both preclinical models for Alzheimer's disease and recent clinical studies. The first preclinical and clinical work has mainly shown a decrease in amyloid burden in mice models and in patients.
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