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Oral Biomimetic Nanotherapeutics for Ulcerative Colitis Targeted Treatment by Repairing Intestinal Epithelial Barrier and Restoring Redox Homeostasis.
ACS Appl Mater Interfaces
January 2025
Department of Pharmaceutics, School of Pharmacy, Ningxia Medical University, No. 1160 Shengli South Street, Yinchuan 750004, PR China.
The structural disruption of intestinal barrier and excessive reactive oxygen/nitrogen species (RONS) generation are two intertwined factors that drive the occurrence and development of ulcerative colitis (UC). Synchronously restoring the intestinal barrier and mitigating excess RONS is a promising strategy for UC management, but its treatment outcomes are still hindered by low drug accumulation and retention in colonic lesions. Inspired by intestine colonizing bacterium, we developed a mucoadhesive probiotic -mimic entinostat-loaded hollow mesopores prussian blue (HMPB) nanotherapeutic (AM@HMPB@E) for UC-targeted therapy via repairing intestinal barrier and scavenging RONS.
View Article and Find Full Text PDFCT feature of irregular extensive ulceration as a predictor of liver metastasis in gastric gastrointestinal stromal tumours.
Eur Radiol
November 2024
Department of Radiology, Yunnan Cancer Centre, Yunnan Cancer Hospital, The Third Affiliated Hospital of Kunming Medical University, Kunming, China.
Objectives: This study aimed to investigate whether the computed tomography (CT) finding of irregular extensive ulceration (IEU) can serve as a predictor of liver metastasis (LIM) in patients with gastric gastrointestinal stromal tumours (GISTs).
Methods: This study retrospectively collected clinical and imaging data from 286 patients diagnosed with low-, intermediate-, or high-risk gastric GISTs, or primary lesions with LIM from three medical institutions. The patients were categorised into non-LIM and LIM groups according to whether they had synchronous or metachronous LIM.
Tumor Cell Implantation from an Oral Advanced Cancer at the Rectal Endoscopic Submucosal Dissection Site: A Case Report and Literature Review.
J Anus Rectum Colon
October 2024
Division of Gastroenterology and Hepatology, Kansai Medical University Medical Center, Moriguchi, Japan.
Article Synopsis
- This report examines instances of tumor cell implantation at sites where colorectal cancer has been surgically removed using endoscopic techniques, highlighting a unique case study involving advanced rectosigmoid cancer.
- The case involved a patient who had upper rectal cancer treated with endoscopic submucosal dissection, leading to cancer recurrence at the ESD site after 7 months, linked to the original advanced cancer.
- The literature review of 10 cases indicates that tumor implantation often occurs at resection sites, especially in areas near advanced cancers, pointing to the necessity of careful monitoring and preventive strategies during endoscopic procedures to reduce this implantation risk.
Imaging findings of thoracic manifestations of Crohn's disease and ulcerative colitis.
Insights Imaging
August 2024
Department of Radiology, Hôpital Cochin, AP-HP.Centre Université Paris Cité, 27 rue du Faubourg Saint-Jacques, 75014, Paris, France.
Thoracic manifestations of inflammatory bowel disease (IBD) are rare, occurring in less than 1% of patients. Unlike most other extra-intestinal manifestations, they predominate in patients with ulcerative colitis rather than in Crohn's disease. In most patients, thoracic involvement follows the onset of IBD by several years.
View Article and Find Full Text PDFSmartwatch interventions in healthcare: A systematic review of the literature.
Int J Med Inform
October 2024
Information Technologies Institute, Centre for Research and Technology Hellas, Thessaloniki, Greece.
Objective: The use of smartwatches has attracted considerable interest in developing smart digital health interventions and improving health and well-being during the past few years. This work presents a systematic review of the literature on smartwatch interventions in healthcare. The main characteristics and individual health-related outcomes of smartwatch interventions within research studies are illustrated, in order to acquire evidence of their benefit and value in patient care.
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