An X-ray procedure for diagnosis of splenic lesions in sjl/j mice with generalized lymphoma, using verographin contained in liposomes, is discussed. Intravenous injections of the preparation were followed by changes in X-ray pictures of the spleen in 9 out of 21 mice aged 11-13 weeks which were interpreted as total or local lesions. The X-ray diagnoses were confirmed by histological examination. Due to application of the method lesions with diameters down to 1 mm may be detected.
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