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Genetic differences between C57BL/6 substrains affect the process of testis differentiation in Y mice.
J Vet Med Sci
April 2019
Department of Animal Science, Graduate School of Agricultural Science, Kobe University, 1-1 Rokkodai, Nada-ku, Kobe, Hyogo 657-8501, Japan.
C57BL/6J-XY (B6J-XY) mice, which have the Y chromosome derived from Mus musculus poschiavinus on a B6J genetic background, form ovotestes or ovaries. Previously, we replaced the genetic background of B6J-XY mice with B6N and found that individuals with testes also appeared in addition to those with ovaries or ovotestes. To investigate the effect of the B6J genetic sequence on the testis differentiation, the genetic background of B6N-XY mice was replaced with B6J again.
View Article and Find Full Text PDFOntogenic and morphological study of gonadal formation in genetically-modified sex reversal XY(POS) mice.
J Vet Med Sci
January 2016
Laboratory of Molecular Morphology, Department of Animal Science, Graduate School of Agricultural Science, Kobe University, Kobe, Hyogo 657-8501, Japan.
Mammalian sexual fate is determined by the presence or absence of sex determining region of the Y chromosome (Sry) in the "bipotential" gonads. Recent studies have demonstrated that both male and female sexual development are induced by distinct and active genetic pathways. Breeding the Y chromosome from Mus m.
View Article and Find Full Text PDFRegulation of sex determination in mice by a non-coding genomic region.
Genetics
July 2014
Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, California 90095-7088 Department of Pediatrics, David Geffen School of Medicine, University of California, Los Angeles, California 90095-7088 Department of Urology, David Geffen School of Medicine, University of California, Los Angeles, California 90095-7088
To identify novel genomic regions that regulate sex determination, we utilized the powerful C57BL/6J-Y(POS) (B6-Y(POS)) model of XY sex reversal where mice with autosomes from the B6 strain and a Y chromosome from a wild-derived strain, Mus domesticus poschiavinus (Y(POS)), show complete sex reversal. In B6-Y(POS), the presence of a 55-Mb congenic region on chromosome 11 protects from sex reversal in a dose-dependent manner. Using mouse genetic backcross designs and high-density SNP arrays, we narrowed the congenic region to a 1.
View Article and Find Full Text PDFThe chromosome 11 region from strain 129 provides protection from sex reversal in XYPOS mice.
Genetics
May 2008
Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
C57BL/6J (B6) mice containing the Mus domesticus poschiavinus Y chromosome, YPOS, develop ovarian tissue, whereas testicular tissue develops in DBA/2J or 129S1/SvImJ (129) mice containing the YPOS chromosome. To identify genes involved in sex determination, we used a congenic strain approach to determine which chromosomal regions from 129Sl/SvImJ provide protection against sex reversal in XYPOS mice of the C57BL/6J.129-YPOS strain.
View Article and Find Full Text PDFAggressive and mating behaviors in two types of sex reversed mice: XY females and XX males.
Arch Sex Behav
February 2008
Biobehavioral Sciences Graduate Degree Program, Department of Psychology, University of Connecticut, Storrs, CT 06269, USA.
Aggressive and mating behaviors were assessed in XX females, XY females, and XY males of the C57BL/6/J/Ei ("C57BL/6" or "B6") strain of mouse. The Y chromosome of the XY females derives from Mus domesticus poschiavinus and the Y chromosome of the XY males derives from Mus musculus. The poschiavinus Y in the C57BL/6 background results in XY mice with either ovaries or ovotestes.
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