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Ixochymostatin, a trypsin inhibitor-like (TIL) protein from Ixodes scapularis, inhibits chymase and impairs vascular permeability.
Int J Biol Macromol
January 2025
Tick-Pathogen Transmission Unit, Laboratory of Bacteriology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, Hamilton, MT, USA. Electronic address:
Ticks obtain a blood meal by lacerating small blood vessels and ingesting the blood that flows to the feeding site, which triggers various host responses. However, ticks face the challenge of wound healing, a process involving hemostasis, inflammation, cell proliferation and migration, and remodeling, hindering blood acquisition. To overcome these obstacles, tick salivary glands produce an array of bioactive molecules.
View Article and Find Full Text PDFExamining downstream effects of concizumab in hemophilia A with a mathematical modeling approach.
J Thromb Haemost
November 2024
Department of Mathematics, University of North Carolina at Chapel Hill, Chapel Hill, NC; Computational Medicine Program, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. Electronic address:
Background: Tissue factor (TF) pathway inhibitor (TFPI) is an anticoagulant protein that inhibits factor (F)Xa, the TF-FVIIa-FXa complex, and early forms of the prothrombinase complex. Concizumab is a monoclonal antibody that blocks FXa inhibition by TFPI and reduces bleeding in hemophilia.
Objectives: To examine how concizumab impacts various reactions of TFPI to restore thrombin generation in hemophilia A using mathematical models.
Identification and validation of coagulation and fibrinolytic-related diagnostic biomarkers for ulcerative colitis by bioinformatics analysis.
Medicine (Baltimore)
September 2024
Renhuai Hospital of Traditional Chinese Medicine, Renhuai City, Guizhou Province, China.
Article Synopsis
- Abnormalities in blood clotting and breakdown processes are important in inflammatory bowel disease, but their specific genetic roles in ulcerative colitis (UC) haven't been systematically studied.
- Researchers analyzed datasets from the Gene Expression Omnibus database, using machine learning to identify key biomarkers related to coagulation and fibrinolysis.
- They found four significant biomarkers (MAP2K1, CREBBP, TAF1, and HP) that are linked to immune pathways and specific immune cells, particularly eosinophils, which could aid in future clinical research on UC.
Activated platelets retain and protect most of their factor XIII-A cargo from proteolytic activation and degradation.
Blood Adv
October 2024
Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC.
Article Synopsis
- - Platelet factor XIII-A (FXIII-A) is a significant protein in platelets, with over 80% remaining attached to platelets even after strong activation, while other proteins like tissue factor pathway inhibitor are released.
- - The retention of FXIII-A during platelet activation is influenced by various factors including STIM1 signaling, microtubule changes, calpain activity, and RhoA activation, but it does not rely on the presence of fibrinogen or plasminogen.
- - Despite being released, the FXIII-A found in the supernatant is cleaved and susceptible to degradation, whereas the FXIII-A remaining with the platelets is intact, indicating distinct biological roles for platelet-derived and plasma
Prevalence and 3-month follow-up of cerebrovascular MRI markers in hospitalized COVID-19 patients: the CORONIS study.
Neuroradiology
September 2024
Department of Neurology, Donders Center for Medical Neuroscience, Radboud University Medical Center, PO Box 9101, Nijmegen, 6500 HB, the Netherlands.
Article Synopsis
- This study aimed to evaluate the prevalence of cerebrovascular MRI markers in patients hospitalized for COVID-19 compared to healthy controls without prior COVID-19 infection or hospitalization.
- Conducted as an observational cohort study, it involved brain MRIs done shortly after discharge and again after three months, focusing on various cerebrovascular issues.
- The results showed no significant difference in cerebrovascular MRI markers between COVID-19 patients and controls, with only a small percentage experiencing new cerebrovascular lesions after three months, suggesting limited impact of COVID-19 on these markers.
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