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Exploring in vitro efficacy of rCHAPk with antibiotic combinations, and promising findings of its therapeutic potential for clinical-originated MRSA wound infection.
Int J Biol Macromol
January 2025
Yıldız Technical University, Faculty of Science and Arts, Department of Molecular Biology and Genetics, Istanbul, Turkey. Electronic address:
The increasing threat of antimicrobial-resistant bacteria, particularly Staphylococcus aureus, which rapidly develops multidrug resistance and commonly colonizes wound surfaces, demands innovative strategies. Phage-encoded endolysins offer a dual-purpose approach as topical therapies for infectious skin wounds and synergistic agents to reduce high-dose antibiotic dependence. This study explores recombinant CHAPk (rCHAPk), efficiently synthesized within 3 h, displaying broad-spectrum antibacterial activity against 11 Gram-positive strains, including resistant variants, with rapid bactericidal kinetics.
View Article and Find Full Text PDFOccurrence and antimicrobial susceptibility of Salmonella enterica in milk along the supply chain, humans, and the environment in Woliata Sodo, Ethiopia.
BMC Microbiol
December 2024
Veterinary Public Health, College of Veterinary Medicine and Agriculture, Addis Ababa University, Bishoftu, Ethiopia.
Background: Salmonella enterica is a major cause of foodborne illness and mortality worldwide, but its presence in milk along the milk supply chain and associated public health risks are under-studied. This research was aimed to investigate the occurrence and antimicrobial susceptibility of Salmonella enterica in milk, milking environments, milkers' hands, and diarrheic patients in Wolaita Sodo, Ethiopia.
Methods: We collected 644 samples from 106 dairy farms that include direct milk from cow, bulk tank milk, milkers' hand swabs, teat surfaces swabs, farm floors swabs, milk storage containers swabs, collectors' bulk milk, retailers' bulk milk, and stool from diarrheic patients.
Structures and mechanism of condensation in nonribosomal peptide synthesis.
Nature
December 2024
Department of Biochemistry and Centre de recherche en biologie structurale, McGill University, Montréal, QC, Canada.
Article Synopsis
- * A critical aspect of NRPS function is the formation of amide bonds between amino acids, a process that has not been fully understood due to its complex nature and the mobile structure of the enzymes involved.
- * Recent research produced a modified NRPS protein, revealing detailed structures that suggest a concerted reaction mechanism, where a key histidine residue stabilizes the reaction instead of acting as a typical general base.
In-situ formation and evaluation of N-nitrosamine drug substance related impurities in glycopeptides implying orbitrap mass spectrometry.
J Pharm Sci
November 2024
Department of Pharmaceutical Analysis, National Institute of Pharmaceutical Education and Research (NIPER), Ahmedabad, India.
Nitrosamines, a class of N-nitroso compounds, have raised significant health concerns due to their established carcinogenicity. ICH M7 enlisted N-nitroso compounds in the so called cohorts of concern due to their carcinogenic effects. Glycopeptides (GPs) are complex molecules composed of peptide and glycan moieties.
View Article and Find Full Text PDFStability of Antibiotics for Use in the Testing of Immediate Drug Allergy Reactions.
J Allergy Clin Immunol Pract
November 2024
Clinical and Health Sciences, University of South Australia, Adelaide, South Australia, Australia.
Article Synopsis
- Limited information exists about the stability of penicillin-based antibiotics for skin testing, prompting a study on 16 parenteral antibiotics to evaluate their physicochemical stability and provide guidelines for clinicians.
- Most antibiotics showed good stability for 2 to 7 days, with amoxicillin/clavulanic acid being a notable exception, dropping below acceptable levels by day 2.
- The research included specific tests for chemical and physical stability, revealing that while many antibiotics maintained acceptable performance, some experienced significant color changes and pH drops over time.
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