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Study on sentinel hosts for surveillance of future COVID-19-like outbreaks.
Sci Rep
October 2024
Department of Epidemiology, School of Public Health, Fudan University, Shanghai, 200433, China.
The spread of SARS-CoV-2 to animals has the potential to evolve independently. In this study, we distinguished several sentinel animal species and genera for monitoring the re-emergence of COVID-19 or the new outbreak of COVID-19-like disease. We analyzed SARS-CoV-2 genomic data from human and nonhuman mammals in the taxonomic hierarchies of species, genus, family and order of their host.
View Article and Find Full Text PDFGenomic Regions Associated with Growth and Reproduction Traits in Pink-Eyed White Mink.
Genes (Basel)
August 2024
Jilin Provincial Key Laboratory for Molecular Biology of Special Economic Animals, Key Laboratory of Special Economic Animal Genetic Breeding and Reproduction, Ministry of Agriculture, Institute of Special Economic Animal and Plant Sciences, The Chinese Academy of Agricultural Sciences, Changchun 130112, China.
Article Synopsis
- Balanced selection in mink breeding is crucial due to the conflicting nature of growth and reproductive traits like total number born (TNB), number born alive (NBA), and body weight (BW).
- The study analyzed SNP genotypes from 219 minks using ddRAD-seq, resulting in over 2.4 million high-quality SNPs for a genome-wide association study (GWAS).
- Findings indicate specific genes linked to TNB, NBA, and BW, providing valuable insights for enhancing mink breeding strategies.
Identification of consensus homozygous regions and their associations with growth and feed efficiency traits in American mink.
BMC Genom Data
July 2024
Department of Animal Science and Aquaculture, Dalhousie University, Truro, NS, Canada.
The recent chromosome-based genome assembly and the newly developed 70K single nucleotide polymorphism (SNP) array for American mink (Neogale vison) facilitate the identification of genetic variants underlying complex traits in this species. The objective of this study was to evaluate the association between consensus runs of homozygosity (ROH) with growth and feed efficiency traits in American mink. A subsample of two mink populations (n = 2,986) were genotyped using the Affymetrix Mink 70K SNP array.
View Article and Find Full Text PDFCharacterization of runs of homozygosity islands in American mink using whole-genome sequencing data.
J Anim Breed Genet
September 2024
Department of Animal Science and Aquaculture, Dalhousie University, Truro, Nova Scotia, Canada.
The genome-wide analysis of runs of homozygosity (ROH) islands can be an effective strategy for identifying shared variants within a population and uncovering important genomic regions related to complex traits. The current study performed ROH analysis to characterize the genome-wide patterns of homozygosity, identify ROH islands and annotated genes within these candidate regions using whole-genome sequencing data from 100 American mink (Neogale vison). After sequence processing, variants were called using GATK and Samtools pipelines.
View Article and Find Full Text PDFp.D446E Variant as a Risk Allele for Arrhythmogenic Phenotypes: Electrophysiological Characterization Reveals a Complex Phenotype Affecting the Slow Delayed Rectifier Potassium Current (IKs) Voltage Dependence by Causing a Hyperpolarizing Shift and a Lack of Response to Protein Kinase A Activation.
Int J Mol Sci
January 2024
Laboratorio de Genómica de Enfermedades Cardiovasculares, Instituto Nacional de Medicina Genómica (INMEGEN), Mexico City 14610, Mexico.
Genetic testing is crucial in inherited arrhythmogenic channelopathies; however, the clinical interpretation of genetic variants remains challenging. Incomplete penetrance, oligogenic, polygenic or multifactorial forms of channelopathies further complicate variant interpretation. We identified the /p.
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