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Dose-Response Relationship of Phloretin Therapy on Water and Glucose Transport during Experimental Peritoneal Dialysis.
Kidney360
January 2025
Lund University, Skåne University Hospital, Clinical Sciences Lund, Department of Nephrology, Lund, Sweden.
Background: Water retention, ultrafiltration insufficiency, and metabolic complications due to abnormally high glucose concentrations are still common problems in patients treated with peritoneal dialysis. Phloretin, a nonselective inhibitor of facilitative glucose transporter channels (GLUT), has shown to improve water transport and lower glucose absorption in experimental peritoneal dialysis. However, the dose-response relationship remains unknown, and we therefore performed a dose-response study to elucidate the pharmacodynamic properties of intra-peritoneal phloretin therapy.
View Article and Find Full Text PDFIntravesical vancomycin for the treatment of Corynebacterium cystitis and struvite bladder stones: A case report.
Urol Case Rep
November 2024
James Buchanan Brady Urological Institute, Division of Pediatric Urology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA.
Urologic patients with anatomic abnormalities can be particularly susceptible to urinary tract infections (UTI). UTI with urease-producing bacteria can promote struvite urinary calculi and pose unique treatment problems. There is potential for rapid stone growth and bacterial eradication can be difficult secondary to urothelial or stone colonization.
View Article and Find Full Text PDFImproving sonographic visualisation of the appendix in a regional referral hospital.
BMJ Open Qual
January 2025
Quality Improvement Coach, University Hospital of Northern British Columbia, Prince George, British Columbia, Canada.
Ultrasound is a first-line and often preferred imaging modality in the diagnosis of acute appendicitis. When the appendix is not visualised during a dedicated appendix ultrasound study, patients may require a CT study, which uses ionising radiation, or undergo conservative clinical observation with the inherent risk of clinical deterioration, perforation and sepsis. Median baseline data, at our hospital imaging department, revealed a rate of combined normal and abnormal appendix visualisation of 34.
View Article and Find Full Text PDFPrevalence and risk factors of the most common multimorbidity among Canadian adults.
PLoS One
January 2025
Faculty of Medicine, Division of Population Health and Applied Health Sciences, Clinical Epidemiology Unit, Memorial University, St. John's, Newfoundland and Labrador, Canada.
Background: The number of persons living with multimorbidity-defined as the co-occurrence of at least two chronic conditions in the same individual-is growing globally, especially in developed countries. Traditionally, this increase has been attributed to a growing aging population, sedentary lifestyle, obesity, low socioeconomic status, and individual genetic susceptibility.
Objective: To investigate the prevalence and associated risk factors of the most common multimorbidity (MCM) among Canadian middle-aged and older adults.
Students as key allies in combating school bullying: Leveraging peer perspectives to recognize victimization in high-risk groups.
J Interpers Violence
January 2025
National Sun Yat-sen University, Kaohsiung, Taiwan.
Bullying in schools remains a critical issue, and teachers often struggle to identify students at risk of victimization. This study explores the prevalence of various forms of bullying among high-risk groups in Taiwanese schools, using peer perspectives to gain insight. A total of 1,732 students (734 males and 998 females) participated in a survey that measured 10 common types of bullying, assessing both students' perceptions and the actual frequency of occurrences over the past 6 months.
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